U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pgc progastricsin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24864, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pgcprovided by RGD
    Official Full Name
    progastricsinprovided by RGD
    Primary source
    RGD:3943
    See related
    EnsemblRapid:ENSRNOG00000014492 AllianceGenome:RGD:3943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PG1; Pg-1; Upg1
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in positive regulation of antibacterial peptide production and proteolysis. Predicted to be active in extracellular space. Orthologous to human PGC (progastricsin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 3.4), Brain (RPKM 2.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pgc in Genome Data Viewer
    Location:
    9q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20755002..20763220, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13257462..13265682, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (15266699..15274917, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene MyoD family inhibitor Neighboring gene transcription factor EB Neighboring gene uncharacterized LOC134480340 Neighboring gene uncharacterized LOC102554309 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of antibacterial peptide production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gastricsin
    Names
    Urinary pepsinogen 1
    progastricsin (pepsinogen C)
    NP_579818.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133284.2NP_579818.1  gastricsin precursor

      See identical proteins and their annotated locations for NP_579818.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P04073
      UniProtKB/TrEMBL
      A6JII4
      Related
      ENSRNOP00000019650.2, ENSRNOT00000019650.5
      Conserved Domains (2) summary
      pfam07966
      Location:1846
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:73391
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      20755002..20763220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)