Guca1a guanylate cyclase activator 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Guca1aprovided by RGD
Official Full Name: guanylate cyclase activator 1Aprovided by RGD
Primary source: RGD:1308712
See related: EnsemblRapid:ENSRNOG00000015402 AllianceGenome:RGD:1308712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Involved in positive regulation of cGMP-mediated signaling and positive regulation of guanylate cyclase activity. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 4.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (21080782..21096221)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (13588988..13598566)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (15609804..15620030)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prolonged illumination up-regulates retinal arrestin and Guca1a/b: a novel mechanism for light adaptation.
Title: Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138598 (e-PCR)
- UniSTS:220685

RH135391 (e-PCR)
- UniSTS:218668

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium sensitive guanylate cyclase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium sensitive guanylate cyclase activator activity	ISO Inferred from Sequence Orthology more info
enables guanylate cyclase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phototransduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cone photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in cone photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in photoreceptor inner segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanylyl cyclase-activating protein 1

Names: guanylate cyclase activator 1a (retina)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106887.2 → NP_001100357.1 guanylyl cyclase-activating protein 1

See identical proteins and their annotated locations for NP_001100357.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6JIK4, D3ZII9

Related

ENSRNOP00000020902.4, ENSRNOT00000020902.8

Conserved Domains (1) summary

COG5126
Location:12 → 163

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

21080782..21096221

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083176.2 → XP_038939104.1 guanylyl cyclase-activating protein 1 isoform X1

Conserved Domains (1) summary

cd00051
Location:18 → 88

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...