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    Taf8 TATA-box binding protein associated factor 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf8provided by RGD
    Official Full Name
    TATA-box binding protein associated factor 8provided by RGD
    Primary source
    RGD:1308423
    See related
    EnsemblRapid:ENSRNOG00000015249 AllianceGenome:RGD:1308423
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tbn
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to be involved in maintenance of protein location in nucleus; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Predicted to act upstream of or within DNA-templated transcription open complex formation; inner cell mass cell proliferation; and regulation of fat cell differentiation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of transcription factor TFIID complex. Orthologous to human TAF8 (TATA-box binding protein associated factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 84.7), Spleen (RPKM 66.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Taf8 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20989554..21009541)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13491892..13511713)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (15513048..15532992)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene uncharacterized LOC134480552 Neighboring gene uncharacterized LOC134480554 Neighboring gene similar to human chromosome 6 open reading frame 132 Neighboring gene uncharacterized LOC134480553 Neighboring gene ciliary microtubule inner protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Voss AK, et al. Development, 2000 Dec. PMID 11076765
    2. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Soutoglou E, et al. Mol Cell Biol, 2005 May. PMID 15870280, Free PMC Article
    3. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, et al. Biochimie, 2013 Apr. PMID 23146842
    4. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Louder RK, et al. Nature, 2016 Mar 31. PMID 27007846, Free PMC Article
    5. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Guermah M, et al. Mol Cell, 2003 Oct. PMID 14580349

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription open complex formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 8
    Names
    TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor
    TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq
    taube nuss homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108197.1 → NP_001101667.1  transcription initiation factor TFIID subunit 8

      See identical proteins and their annotated locations for NP_001101667.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473987
      UniProtKB/TrEMBL
      A0A8I6AWS9, A6JIJ8, D3ZY89
      Related
      ENSRNOP00000097776.2, ENSRNOT00000094728.2
      Conserved Domains (2) summary
      cd08049
      Location:142 → 195
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:27 → 104
      Bromo_TP; Bromodomain associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      20989554..21009541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766860.3 → XP_008765082.1  transcription initiation factor TFIID subunit 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZ64
      Conserved Domains (2) summary
      cd08049
      Location:142 → 195
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:27 → 104
      Bromo_TP; Bromodomain associated

    2. XM_039083489.2 → XP_038939417.1  transcription initiation factor TFIID subunit 8 isoform X3

      UniProtKB/TrEMBL
      A6JIJ7
      Conserved Domains (2) summary
      cd08049
      Location:142 → 195
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:27 → 104
      Bromo_TP; Bromodomain associated

    3. XM_039083490.2 → XP_038939418.1  transcription initiation factor TFIID subunit 8 isoform X3

      UniProtKB/TrEMBL
      A6JIJ7
      Conserved Domains (2) summary
      cd08049
      Location:142 → 195
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:27 → 104
      Bromo_TP; Bromodomain associated

    4. XM_008766862.4 → XP_008765084.1  transcription initiation factor TFIID subunit 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6B3B9, A6JIJ6
      Related
      ENSRNOP00000095795.1, ENSRNOT00000094919.2
      Conserved Domains (2) summary
      cd08049
      Location:142 → 195
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:27 → 104
      Bromo_TP; Bromodomain associated
    Nucleotide Protein Strain
    Heading Accession and Version

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