Oxtr oxytocin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oxtrprovided by RGD
Official Full Name: oxytocin receptorprovided by RGD
Primary source: RGD:3239
See related: EnsemblRapid:ENSRNOG00000005806 AllianceGenome:RGD:3239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OTR; OT-R; OTR1
Summary: Enables ionotropic glutamate receptor binding activity; oxytocin receptor activity; and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; estrous cycle; and positive regulation of synaptic transmission. Located in adherens junction; apical plasma membrane; and microvillus. Used to study gastric ulcer. Biomarker of hypertension. Orthologous to human OXTR (oxytocin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 17.2), Uterus (RPKM 11.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (147154374..147171723, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (145598549..145614674, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (144399326..144417598, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.
Title: Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.
Brief versus long maternal separation in lactating rats: Consequences on maternal behavior, emotionality, and brain oxytocin receptor binding.
Title: Brief versus long maternal separation in lactating rats: Consequences on maternal behavior, emotionality, and brain oxytocin receptor binding.
Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat.
Title: Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat.
Oxytocin receptor expression and epigenetic regulation in the anterior cingulate cortex of individuals with a history of severe childhood abuse.
Title: Oxytocin receptor expression and epigenetic regulation in the anterior cingulate cortex of individuals with a history of severe childhood abuse.
Regulation of oxytocin receptor gene expression in obsessive-compulsive disorder: a possible role for the microbiota-host epigenetic axis.
Title: Regulation of oxytocin receptor gene expression in obsessive-compulsive disorder: a possible role for the microbiota-host epigenetic axis.
Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.
Title: Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.
Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2.
Title: Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2.
Paternal stress in rats increased oxytocin, oxytocin receptor, and arginine vasopressin gene expression in the male offspring amygdala with no effect on their social interaction behaviors.
Title: Paternal stress in rats increased oxytocin, oxytocin receptor, and arginine vasopressin gene expression in the male offspring amygdala with no effect on their social interaction behaviors.
Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms.
Title: Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms.
Oxytocin receptor expression in the midbrain dorsal raphe is dynamic across female reproduction in rats.
Title: Oxytocin receptor expression in the midbrain dorsal raphe is dynamic across female reproduction in rats.

Submit: New GeneRIF Correction See all GeneRIFs (67)

General gene information

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Markers

PMC170950P1 (e-PCR)
- UniSTS:271619

AU047790 (e-PCR)
- UniSTS:110171

Oxtr (e-PCR), detects polymorphism
- UniSTS:527471

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxytocin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxytocin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal process involved in parturition	IBA Inferred from Biological aspect of Ancestor more info
involved_in maternal process involved in parturition	IEP Inferred from Expression Pattern more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of penile erection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of uterine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm ejaculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in suckling behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telencephalon development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oxytocin receptor

Names: oxcytocin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012871.4 → NP_037003.2 oxytocin receptor

See identical proteins and their annotated locations for NP_037003.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P70536, Q53ZC5

UniProtKB/TrEMBL

A6IBN2, Q8R561

Related

ENSRNOP00000007724.1, ENSRNOT00000007724.4

Conserved Domains (2) summary

pfam00001
Location:56 → 328

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:46 → 146

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

147154374..147171723 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285603.1 → XP_063141673.1 oxytocin receptor isoform X1

UniProtKB/Swiss-Prot

P70536, Q53ZC5

UniProtKB/TrEMBL

A6IBN2, Q8R561
XM_063285602.1 → XP_063141672.1 oxytocin receptor isoform X1

UniProtKB/Swiss-Prot

P70536, Q53ZC5

UniProtKB/TrEMBL

A6IBN2, Q8R561
XM_063285601.1 → XP_063141671.1 oxytocin receptor isoform X1

UniProtKB/Swiss-Prot

P70536, Q53ZC5

UniProtKB/TrEMBL

A6IBN2, Q8R561