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    Mdfi MyoD family inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mdfiprovided by RGD
    Official Full Name
    MyoD family inhibitorprovided by RGD
    Primary source
    RGD:1560271
    See related
    EnsemblRapid:ENSRNOG00000014987 AllianceGenome:RGD:1560271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560271
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and identical protein binding activity. Predicted to be involved in dorsal/ventral axis specification; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to act upstream of or within embryonic skeletal system morphogenesis and trophoblast giant cell differentiation. Predicted to be active in nucleus. Orthologous to human MDFI (MyoD family inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 18.3), Kidney (RPKM 13.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mdfi in Genome Data Viewer
    Location:
    9q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20654359..20672768)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13156806..13175218)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (15166118..15184469)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554116 Neighboring gene forkhead box P4 Neighboring gene uncharacterized LOC134480340 Neighboring gene transcription factor EB Neighboring gene uncharacterized LOC102554309 Neighboring gene progastricsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. Kusano S, et al. Mol Cell Biol, 2002 Sep. PMID 12192039, Free PMC Article
    2. Inhibition of Tcf3 binding by I-mfa domain proteins. Snider L, et al. Mol Cell Biol, 2001 Mar. PMID 11238923, Free PMC Article
    3. Requirement of the mouse I-mfa gene for placental development and skeletal patterning. Kraut N, et al. EMBO J, 1998 Nov 2. PMID 9799236, Free PMC Article
    4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
    5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within trophoblast giant cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myoD family inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109301.2 → NP_001102771.1  myoD family inhibitor

      See identical proteins and their annotated locations for NP_001102771.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GLH7, A6JIH8, B0BN88, F7EL63
      Related
      ENSRNOP00000020432.3, ENSRNOT00000020432.6
      Conserved Domains (1) summary
      pfam15316
      Location:88 → 247
      MDFI; MyoD family inhibitor

    2. NM_001432172.1 → NP_001419101.1  myoD family inhibitor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GLH7, A6JIH8, B0BN88, F7EL63

    3. NM_001432173.1 → NP_001419102.1  myoD family inhibitor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GLH7, A6JIH8, B0BN88, F7EL63

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      20654359..20672768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244476.5 → XP_006244538.1  myoD family inhibitor isoform X1

      Conserved Domains (1) summary
      pfam15316
      Location:88 → 247
      MDFI; MyoD family inhibitor

    2. XM_006244475.5 → XP_006244537.1  myoD family inhibitor isoform X1

      Conserved Domains (1) summary
      pfam15316
      Location:88 → 247
      MDFI; MyoD family inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version

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