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    Capn11 calpain 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408218, updated on 9-Dec-2024

    Summary

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    Symbol
    Capn11provided by RGD
    Full Name
    calpain 11provided by RGD
    Primary source
    RGD:1302946
    See related
    EnsemblRapid:ENSRNOG00000026025 AllianceGenome:RGD:1302946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle. Predicted to be active in cytoplasm. Orthologous to human CAPN11 (calpain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 86.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Capn11 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22841500..22863042)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (15344059..15365604)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17728845..17750357)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690501 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene transmembrane protein 63B Neighboring gene solute carrier family 29 member 1 Neighboring gene myomixer, myoblast fusion factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Calpain 11 is unique to mouse spermatogenic cells. Ben-Aharon I, et al. Mol Reprod Dev, 2006 Jun. PMID 16541461, Free PMC Article
    2. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calpain 11
    Names
    CANP 11
    calcium-activated neutral proteinase 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002806.2 → NP_001002806.2  calpain 11

      See identical proteins and their annotated locations for NP_001002806.2

      Status: VALIDATED

      Source sequence(s)
      BC097256
      UniProtKB/Swiss-Prot
      Q4V8Q1, Q6IE72
      UniProtKB/TrEMBL
      D3ZXF4
      Related
      ENSRNOP00000059934.3, ENSRNOT00000065754.6
      Conserved Domains (3) summary
      cd00051
      Location:591 → 641
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:367 → 520
      Calpain_III; Calpain large subunit, domain III

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22841500..22863042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084029.2 → XP_038939957.1  calpain 11 isoform X1

      UniProtKB/Swiss-Prot
      Q4V8Q1, Q6IE72
      Related
      ENSRNOP00000083385.1, ENSRNOT00000114818.2
      Conserved Domains (4) summary
      cd00214
      Location:367 → 521
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd15897
      Location:543 → 571
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:543 → 711
      EFh_PEF; The penta-EF hand (PEF) family
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease

    2. XM_063267562.1 → XP_063123632.1  calpain 11 isoform X3

      UniProtKB/Swiss-Prot
      Q4V8Q1, Q6IE72

    3. XM_063267563.1 → XP_063123633.1  calpain 11 isoform X4

      UniProtKB/TrEMBL
      F1M7U2

    4. XM_063267561.1 → XP_063123631.1  calpain 11 isoform X2

      UniProtKB/TrEMBL
      F1M7U2
      Related
      ENSRNOP00000061253.4, ENSRNOT00000067104.5

    5. XM_063267564.1 → XP_063123634.1  calpain 11 isoform X5

      UniProtKB/TrEMBL
      A6JIX3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8Q1.2 GenPept UniProtKB/Swiss-Prot:Q4V8Q1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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