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    Tecr trans-2,3-enoyl-CoA reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 191576, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tecrprovided by RGD
    Official Full Name
    trans-2,3-enoyl-CoA reductaseprovided by RGD
    Primary source
    RGD:620376
    See related
    EnsemblRapid:ENSRNOG00000021808 AllianceGenome:RGD:620376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SC2; Gpsn2
    Summary
    Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in fatty acid elongation; sphingolipid metabolic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14. Orthologous to human TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1022.4), Muscle (RPKM 836.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tecr in Genome Data Viewer
    Location:
    19q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41431422..41472880)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24526700..24568168)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24705478..24732024, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cytochrome c-like Neighboring gene ribosomal protein S10, pseudogene 10 Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene ribosomal protein S2, pseudogene 7 Neighboring gene uncharacterized LOC134483333 Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene ribosomal protein S2, pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a novel mRNA using an antibody directed against synaptic glycoproteins. Johnston IG, et al. J Neurosci Res, 1992 Jun. PMID 1404491
    2. Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation. Wakashima T, et al. J Biol Chem, 2014 Sep 5. PMID 25049234, Free PMC Article
    3. Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile. Abe K, et al. J Biol Chem, 2013 Dec 20. PMID 24220030, Free PMC Article
    4. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. Moon YA, et al. J Biol Chem, 2003 Feb 28. PMID 12482854
    5. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain enoyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain enoyl-CoA reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-long-chain enoyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain enoyl-CoA reductase
    Names
    TER
    glycoprotein, synaptic 2
    neuroprotective protein 13
    synaptic glycoprotein SC2
    NP_001385608.1
    NP_001385609.1
    NP_001385610.1
    NP_001385611.1
    NP_612558.1
    XP_063133837.1
    XP_063133838.1
    XP_063133839.1
    XP_063133840.1
    XP_063133841.1
    XP_063133842.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398679.1 → NP_001385608.1  very-long-chain enoyl-CoA reductase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AKU7
      Related
      ENSRNOP00000083676.2, ENSRNOT00000115783.2
      Conserved Domains (2) summary
      PLN02560
      Location:38 → 290
      PLN02560; enoyl-CoA reductase
      cl28922
      Location:3 → 66
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001398680.1 → NP_001385609.1  very-long-chain enoyl-CoA reductase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AI38, A0A8I6AKU7
      Conserved Domains (2) summary
      PLN02560
      Location:72 → 324
      PLN02560; enoyl-CoA reductase
      cl28922
      Location:37 → 100
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. NM_001398681.1 → NP_001385610.1  very-long-chain enoyl-CoA reductase isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AKU7, A0A8I6ALN4
      Conserved Domains (1) summary
      PLN02560
      Location:57 → 339
      PLN02560; enoyl-CoA reductase

    4. NM_001398682.1 → NP_001385611.1  very-long-chain enoyl-CoA reductase isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IYE1
      Conserved Domains (1) summary
      PLN02560
      Location:3 → 174
      PLN02560; enoyl-CoA reductase

    5. NM_138549.2 → NP_612558.1  very-long-chain enoyl-CoA reductase isoform 1

      See identical proteins and their annotated locations for NP_612558.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q64232
      UniProtKB/TrEMBL
      A0A8I6AKU7, B3SVE9
      Related
      ENSRNOP00000080279.1, ENSRNOT00000096596.2
      Conserved Domains (1) summary
      PLN02560
      Location:23 → 305
      PLN02560; enoyl-CoA reductase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41431422..41472880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277772.1 → XP_063133842.1  very-long-chain enoyl-CoA reductase isoform X5

      UniProtKB/TrEMBL
      A6IYE1

    2. XM_063277771.1 → XP_063133841.1  very-long-chain enoyl-CoA reductase isoform X5

      UniProtKB/TrEMBL
      A6IYE1

    3. XM_063277770.1 → XP_063133840.1  very-long-chain enoyl-CoA reductase isoform X4

      UniProtKB/TrEMBL
      A0A8I6AKU7

    4. XM_063277769.1 → XP_063133839.1  very-long-chain enoyl-CoA reductase isoform X3

      UniProtKB/TrEMBL
      A0A8I6AKU7

    5. XM_063277767.1 → XP_063133837.1  very-long-chain enoyl-CoA reductase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AKU7

    6. XM_063277768.1 → XP_063133838.1  very-long-chain enoyl-CoA reductase isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKU7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64232.1 GenPept UniProtKB/Swiss-Prot:Q64232

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