Ppef2 protein phosphatase with EF-hand domain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppef2provided by RGD
Official Full Name: protein phosphatase with EF-hand domain 2provided by RGD
Primary source: RGD:1307093
See related: EnsemblRapid:ENSRNOG00000052061 AllianceGenome:RGD:1307093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heat shock protein binding activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and negative regulation of peptidyl-threonine phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human PPEF2 (protein phosphatase with EF-hand domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 8.7), Lung (RPKM 6.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (16081706..16115903)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (15797414..15831620)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (17306825..17333588, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in detection of stimulus involved in sensory perception	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase with EF-hands 2

Names: protein phosphatase, EF hand calcium-binding domain 2

NP_001100680.1

EC 3.1.3.16

XP_038947795.1

EC 3.1.3.16

XP_038947796.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107210.2 → NP_001100680.1 serine/threonine-protein phosphatase with EF-hands 2

See identical proteins and their annotated locations for NP_001100680.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A6KKA0, A6KKA1, D3ZN69

Related

ENSRNOP00000075449.1, ENSRNOT00000077636.3

Conserved Domains (5) summary

smart00015
Location:21 → 40

IQ; Calmodulin-binding motif

smart00156
Location:141 → 541

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd00051
Location:658 → 723

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd07420
Location:122 → 538

MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain

pfam13499
Location:658 → 722

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

16081706..16115903

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091867.2 → XP_038947795.1 serine/threonine-protein phosphatase with EF-hands 2 isoform X1

UniProtKB/TrEMBL

A6KKA1

Conserved Domains (4) summary

smart00015
Location:60 → 79

IQ; Calmodulin-binding motif

COG5126
Location:617 → 761

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:697 → 762

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd07420
Location:161 → 577

MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
XM_039091868.2 → XP_038947796.1 serine/threonine-protein phosphatase with EF-hands 2 isoform X2

Conserved Domains (3) summary

COG5126
Location:322 → 466

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

pfam13499
Location:399 → 467

EF-hand_7; EF-hand domain pair

cl13995
Location:1 → 282

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain