Gnat1 G protein subunit alpha transducin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnat1provided by RGD
Official Full Name: G protein subunit alpha transducin 1provided by RGD
Primary source: RGD:1304683
See related: EnsemblRapid:ENSRNOG00000017589 AllianceGenome:RGD:1304683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hg1f
Summary: Enables GTP binding activity. Involved in several processes, including G protein-coupled opsin signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and positive regulation of cyclic-nucleotide phosphodiesterase activity. Located in several cellular components, including apical plasma membrane; photoreceptor inner segment; and photoreceptor outer segment. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to human GNAT1 (G protein subunit alpha transducin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 20.7), Kidney (RPKM 7.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117229575..117234311, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108350935..108355671, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116433302..116438038, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

PMC17675P1 (e-PCR)
- UniSTS:271643

RH137015 (e-PCR)
- UniSTS:219104

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opsin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within background adaptation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of light stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of light stimulus involved in visual perception	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
involved_in detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eye photoreceptor cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phototransduction	ISO Inferred from Sequence Orthology more info
involved_in phototransduction, visible light	IBA Inferred from Biological aspect of Ancestor more info
involved_in phototransduction, visible light	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclic-nucleotide phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to light intensity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to light intensity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal cone cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal rod cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of umami taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(t) subunit alpha-1

Names: guanine nucleotide binding protein (G protein), alpha transducing 1; guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; guanine nucleotide binding protein, alpha transducing 1; heterotrimeric guanine nucleotide-binding protein 1f; rod-type transducin alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.