Nudt1 nudix hydrolase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt1provided by RGD
Official Full Name: nudix hydrolase 1provided by RGD
Primary source: RGD:621080
See related: EnsemblRapid:ENSRNOG00000001260 AllianceGenome:RGD:621080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mth1
Summary: Predicted to enable nucleoside triphosphate diphosphatase activity and snoRNA binding activity. Involved in male gonad development and response to cadmium ion. Located in acrosomal vesicle; extracellular space; and nuclear membrane. Biomarker of hypertension. Orthologous to human NUDT1 (nudix hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 66.6), Spleen (RPKM 34.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (19416411..19423448, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (14302514..14309559, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (16391578..16398771, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
Title: Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
MTH1 is downregulated by HS-1200, which inhibits hepatocarcinogenesis and improves liver function
Title: Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.
distribution of MTH1, associated apparently with the conditional changes in the dynamics of synthesis of nucleic acids, assisted by this protein
Title: Intracellular distribution of the antimutagenic enzyme MTH1 in the liver, kidney and testis of F344 rats and its modulation by cadmium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-hydroxy-ATP hydrolase activity	ISO Inferred from Sequence Orthology more info
enables 2-hydroxy-ATP hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 2-hydroxy-dATP hydrolase activity	ISO Inferred from Sequence Orthology more info
enables 2-hydroxy-dATP hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISO Inferred from Sequence Orthology more info
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables N6-methyl-(d)ATP hydrolase activity	IEA Inferred from Electronic Annotation more info
enables O6-methyl-dGTP hydrolase activity	IEA Inferred from Electronic Annotation more info
enables dATP diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables snoRNA binding	ISO Inferred from Sequence Orthology more info
enables snoRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA protection	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA protection	ISO Inferred from Sequence Orthology more info
involved_in DNA protection	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in purine nucleoside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleoside catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: oxidized purine nucleoside triphosphate hydrolase

Names: 2-hydroxy-dATP diphosphatase; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; methylated purine nucleoside triphosphate hydrolase; mutT human homolog (8-oxo-dGTPase); nucleoside diphosphate-linked moiety X motif 1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; nudix motif 1; nudix-type motif 1

NP_476461.1

EC 3.6.1.56

XP_006248973.1

EC 3.6.1.56

XP_038944963.1

EC 3.6.1.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057120.2 → NP_476461.1 oxidized purine nucleoside triphosphate hydrolase

See identical proteins and their annotated locations for NP_476461.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P53369

UniProtKB/TrEMBL

A6K1T0

Related

ENSRNOP00000001700.5, ENSRNOT00000001700.8

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

19416411..19423448 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248911.5 → XP_006248973.1 oxidized purine nucleoside triphosphate hydrolase isoform X1

See identical proteins and their annotated locations for XP_006248973.1

UniProtKB/Swiss-Prot

P53369

UniProtKB/TrEMBL

A6K1T0

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
XM_039089035.2 → XP_038944963.1 oxidized purine nucleoside triphosphate hydrolase isoform X1

UniProtKB/Swiss-Prot

P53369

UniProtKB/TrEMBL

A6K1T0

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...