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    Tspan12 tetraspanin 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362326, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tspan12provided by RGD
    Official Full Name
    tetraspanin 12provided by RGD
    Primary source
    RGD:1311102
    See related
    EnsemblRapid:ENSRNOG00000059016 AllianceGenome:RGD:1311102
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tm4sf12
    Summary
    Predicted to be involved in cell surface receptor signaling pathway; regulation of angiogenesis; and retina layer formation. Predicted to act upstream of or within Norrin signaling pathway and maintenance of blood-brain barrier. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 5. Orthologous to human TSPAN12 (tetraspanin 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 331.3), Lung (RPKM 278.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspan12 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (51279562..51355030, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (50313768..50389246, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (48852823..48953240, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily D member 2 Neighboring gene tubulin beta chain-like Neighboring gene uncharacterized LOC134486737 Neighboring gene cytochrome c oxidase subunit 6C-2-like Neighboring gene inhibitor of growth family, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Junge HJ, et al. Cell, 2009 Oct 16. PMID 19837033
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109305

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables Wnt receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables Wnt receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Norrin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within maintenance of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina layer formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-12
    Names
    transmembrane 4 superfamily member 12
    tspan-12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015026.1 → NP_001015026.1  tetraspanin-12

      See identical proteins and their annotated locations for NP_001015026.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092623
      UniProtKB/Swiss-Prot
      Q569A2
      UniProtKB/TrEMBL
      A0A8I6GLC8
      Related
      ENSRNOP00000072130.1, ENSRNOT00000083938.3
      Conserved Domains (2) summary
      cd03157
      Location:116 → 218
      TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 244
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      51279562..51355030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762788.4 → XP_008761010.1  tetraspanin-12 isoform X1

      See identical proteins and their annotated locations for XP_008761010.1

      UniProtKB/Swiss-Prot
      Q569A2
      UniProtKB/TrEMBL
      A0A8I6GLC8
      Conserved Domains (2) summary
      cd03157
      Location:116 → 218
      TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 244
      Tetraspannin; Tetraspanin family

    2. XM_039107771.2 → XP_038963699.1  tetraspanin-12 isoform X4

      Conserved Domains (1) summary
      cd03157
      Location:1 → 99
      TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    3. XM_008762790.3 → XP_008761012.1  tetraspanin-12 isoform X3

      Conserved Domains (2) summary
      cl02781
      Location:116 → 206
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:9 → 194
      Tetraspannin; Tetraspanin family

    4. XM_017592685.3 → XP_017448174.1  tetraspanin-12 isoform X2

    5. XM_063286235.1 → XP_063142305.1  tetraspanin-12 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q569A2.1 GenPept UniProtKB/Swiss-Prot:Q569A2

    Gene LinkOut

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