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    Syt15 synaptotagmin 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syt15provided by RGD
    Official Full Name
    synaptotagmin 15provided by RGD
    Primary source
    RGD:727964
    See related
    EnsemblRapid:ENSRNOG00000051688 AllianceGenome:RGD:727964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    sytXV
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in regulation of calcium ion-dependent exocytosis and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYT15 (synaptotagmin 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 19.5), Kidney (RPKM 10.9) and 9 other tissues See more
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    Genomic context

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    See Syt15 in Genome Data Viewer
    Location:
    16p15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (9538740..9549548)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (9532478..9543288)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10554136..10564934)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene neuropeptide Y receptor Y4 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene shieldin complex subunit 2 Neighboring gene ZW10 interacting kinetochore protein, pseudogene 1 Neighboring gene small nucleolar RNA SNORA15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis. Ishihara Y, et al. Toxicol Lett, 2003 Apr 30. PMID 12765241
    2. Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV. Fukuda M. Biochem Biophys Res Commun, 2003 Jun 20. PMID 12788067
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. molecular cloning and structure
      Title: Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91393

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-15
    Names
    synaptotagmin XV

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181632.2 → NP_853663.2  synaptotagmin-15

      See identical proteins and their annotated locations for NP_853663.2

      Status: PROVISIONAL

      Source sequence(s)
      BC084685
      UniProtKB/Swiss-Prot
      P59926
      UniProtKB/TrEMBL
      A0A0G2KAX3, A6KFS7, F1LQ33, Q5XFY6
      Related
      ENSRNOP00000075561.2, ENSRNOT00000079030.3
      Conserved Domains (2) summary
      cd08390
      Location:150 → 270
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08409
      Location:280 → 417
      C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      9538740..9549548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59926.1 GenPept UniProtKB/Swiss-Prot:P59926

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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