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    Dennd10 DENN domain containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308009, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dennd10provided by RGD
    Official Full Name
    DENN domain containing 10provided by RGD
    Primary source
    RGD:1308326
    See related
    EnsemblRapid:ENSRNOG00000010230 AllianceGenome:RGD:1308326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam45a; RGD1308326
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Predicted to be active in late endosome. Orthologous to several human genes including DENND10 (DENN domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 160.4), Kidney (RPKM 108.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dennd10 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (269937023..269960506)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (259950955..259974459)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (282188080..282211588)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene small nucleolar RNA SNORA19 Neighboring gene uncharacterized LOC134485268 Neighboring gene sideroflexin 4 Neighboring gene uncharacterized LOC134485269 Neighboring gene peroxiredoxin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes. Zhang J, et al. Biochim Biophys Acta Mol Cell Res, 2019 May. PMID 30771381
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 10
    Names
    family with sequence similarity 45, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127681.2 → NP_001121153.1  DENN domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001121153.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JIA9
      Related
      ENSRNOP00000101312.1, ENSRNOT00000148269.1
      Conserved Domains (1) summary
      cl40631
      Location:37 → 143
      SPA; Stabilization of polarity axis

    2. NM_001398802.1 → NP_001385731.1  DENN domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JIA6
      Related
      ENSRNOP00000013845.8, ENSRNOT00000013845.9
      Conserved Domains (1) summary
      cl40631
      Location:158 → 264
      SPA; Stabilization of polarity axis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      269937023..269960506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288305.1 → XP_063144375.1  DENN domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A6JIA9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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