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    Hyal3 hyaluronidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300993, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hyal3provided by RGD
    Official Full Name
    hyaluronidase 3provided by RGD
    Primary source
    RGD:1303334
    See related
    EnsemblRapid:ENSRNOG00000077390 AllianceGenome:RGD:1303334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hyaluronoglucuronidase activity and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including cellular response to UV-B; cellular response to cytokine stimulus; and hyaluronan catabolic process. Predicted to be located in several cellular components, including cytoplasmic vesicle; lysosome; and sperm midpiece. Predicted to be active in acrosomal vesicle. Orthologous to human HYAL3 (hyaluronidase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 99.8), Lung (RPKM 53.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hyal3 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117133028..117138663)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108254385..108260020)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116336512..116342147)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronidase 2 Neighboring gene hyaluronidase 1 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene interferon-related developmental regulator 2 Neighboring gene leucine-rich single-pass membrane protein 2 Neighboring gene semaphorin 3B Neighboring gene uncharacterized LOC120094260

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hyaluronoglucuronidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hyaluronoglucuronidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hyalurononglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables hyalurononglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hyalurononglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hyalurononglucosaminidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV-B IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hyaluronan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hyaluronan catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hyaluronan catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hyaluronan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ovarian follicle atresia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle atresia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in penetration of zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in penetration of zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of acrosomal vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm midpiece ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    hyaluronidase-3
    Names
    hyal-3
    hyaluronoglucosaminidase 3
    NP_997482.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207599.2NP_997482.2  hyaluronidase-3 precursor

      See identical proteins and their annotated locations for NP_997482.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097259
      UniProtKB/Swiss-Prot
      Q4V8Q0, Q76HM9
      UniProtKB/TrEMBL
      A6I2Y6
      Related
      ENSRNOP00000106324.1, ENSRNOT00000134913.1
      Conserved Domains (1) summary
      pfam01630
      Location:26350
      Glyco_hydro_56; Hyaluronidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117133028..117138663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)