Pcdhac2 protocadherin alpha subfamily C, 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Symbol: Pcdhac2provided by RGD
Full Name: protocadherin alpha subfamily C, 2provided by RGD
Primary source: RGD:735216
See related: AllianceGenome:RGD:735216
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rCNRvc2
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within serotonergic neuron axon guidance. Predicted to be located in plasma membrane. Orthologous to human PCDHAC2 (protocadherin alpha subfamily C, 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: not in current annotation release
Expression: Biased expression in Lung (RPKM 166.1), Brain (RPKM 165.6) and 5 other tissues See more
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Genomic context

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See Pcdhac2 in Genome Data Viewer

Location:: 18p11

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

PMC312645P1 (e-PCR)
- UniSTS:272906

RH91795 (e-PCR)
- UniSTS:85819

IB766 (e-PCR)
- UniSTS:42573

WI-19540 (e-PCR)
- UniSTS:63886

NoName (e-PCR)
- UniSTS:547524

Pcdha (e-PCR), detects polymorphism
- UniSTS:547524

RH65516 (e-PCR)
- UniSTS:66009

PMC311048P1 (e-PCR)
- UniSTS:272867

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within serotonergic neuron axon guidance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin alpha-C2

Names: cadherin-related neuronal receptor c2; protocadherin alpha c2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201422.1 → NP_958825.1 protocadherin alpha-C2 precursor

See identical proteins and their annotated locations for NP_958825.1

Status: PROVISIONAL

Source sequence(s)

AB113398

UniProtKB/TrEMBL

Q767H7

Conserved Domains (4) summary

cd11304
Location:260 → 360

Cadherin_repeat; Cadherin tandem repeat domain

pfam15974
Location:855 → 998

Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region

pfam16492
Location:702 → 807

Cadherin_C_2; Cadherin cytoplasmic C-terminal

cl09101
Location:42 → 126

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus