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    Alpk3 alpha-kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alpk3provided by RGD
    Official Full Name
    alpha-kinase 3provided by RGD
    Primary source
    RGD:1309860
    See related
    EnsemblRapid:ENSRNOG00000011659 AllianceGenome:RGD:1309860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309860
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in cardiac muscle cell development. Predicted to act upstream of or within heart development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human ALPK3 (alpha kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 817.0), Heart (RPKM 405.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alpk3 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144423690..144471534)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135014455..135062294)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142882997..142931940)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SEC11 homolog A, signal peptidase complex subunit Neighboring gene zinc finger protein 592 Neighboring gene solute carrier family 28 member 1 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene phosphodiesterase 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cardiomyopathy in α-kinase 3 (ALPK3)-deficient mice. Van Sligtenhorst I, et al. Vet Pathol, 2012 Jan. PMID 21441111
    2. A novel myocyte-specific gene Midori promotes the differentiation of P19CL6 cells into cardiomyocytes. Hosoda T, et al. J Biol Chem, 2001 Sep 21. PMID 11418590
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-protein kinase 3
    NP_001178824.1
    XP_008757768.1
    XP_038940952.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191895.2 → NP_001178824.1  alpha-protein kinase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZR19, D3ZH28
      Related
      ENSRNOP00000015899.4, ENSRNOT00000015898.7
      Conserved Domains (4) summary
      smart00408
      Location:90 → 159
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:1271 → 1343
      IG_like; Immunoglobulin like
      smart00811
      Location:1376 → 1596
      Alpha_kinase; Alpha-kinase family
      pfam07679
      Location:77 → 169
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144423690..144471534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085024.2 → XP_038940952.1  alpha-protein kinase 3 isoform X2

      Conserved Domains (3) summary
      PHA03307
      Location:882 → 1254
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00096
      Location:77 → 79
      Ig; Ig strand A [structural motif]
      cl11960
      Location:77 → 169
      Ig; Immunoglobulin domain

    2. XM_008759546.4 → XP_008757768.1  alpha-protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR19, A0A8I6A4R0
      Related
      ENSRNOP00000088261.1, ENSRNOT00000117513.2
      Conserved Domains (4) summary
      smart00408
      Location:77 → 146
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:1258 → 1330
      IG_like; Immunoglobulin like
      smart00811
      Location:1363 → 1583
      Alpha_kinase; Alpha-kinase family
      pfam07679
      Location:64 → 156
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein Strain
    Heading Accession and Version

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