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    Rps2 ribosomal protein S2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rps2provided by RGD
    Official Full Name
    ribosomal protein S2provided by RGD
    Primary source
    RGD:619887
    See related
    EnsemblRapid:ENSRNOG00000014179 AllianceGenome:RGD:619887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rps2r1
    Summary
    A structural constituent of ribosome. Involved in formation of translation preinitiation complex; response to ethanol; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Orthologous to human RPS2 (ribosomal protein S2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 5380.6), Thymus (RPKM 4322.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14251841..14253697)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13747316..13749165)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14088171..14090020)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transducin (beta)-like 3 Neighboring gene ring finger protein 151 Neighboring gene small nucleolar RNA ACA64 Neighboring gene small nucleolar RNA, H/ACA box 64 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 Neighboring gene ribosomal protein L3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Localization of rat liver ribosomal protein S2 and its involvement in initiation factor eIF-2 binding to the 40 S ribosomal subunit. Noll F, et al. FEBS Lett, 1978 Mar 1. PMID 344063
    2. Primary structure of rat ribosomal protein S2. A ribosomal protein with arginine-glycine tandem repeats and RGGF motifs that are associated with nucleolar localization and binding to ribonucleic acids. Suzuki K, et al. J Biol Chem, 1991 Oct 25. PMID 1939063
    3. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. Antoine M, et al. Biochem Biophys Res Commun, 2005 Sep 16. PMID 16061210
    4. Physical mapping and structural analysis of new gene families RT1.S and Rps2r in the grc region of the rat major histocompatibility complex. Salgar SK, et al. Immunogenetics, 1997. PMID 9089092
    5. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. Choi S, et al. Biochim Biophys Acta, 2008 Sep. PMID 18573314

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interleukin-4 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of translation preinitiation complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS5
    Names
    40S ribosomal protein S2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031838.3 → NP_114026.3  small ribosomal subunit protein uS5

      See identical proteins and their annotated locations for NP_114026.3

      Status: PROVISIONAL

      Source sequence(s)
      AI713815, CB324420, CD372915
      UniProtKB/Swiss-Prot
      P27952, Q4G062
      UniProtKB/TrEMBL
      E9PU05, O55215
      Related
      ENSRNOP00000102464.1, ENSRNOT00000162258.1
      Conserved Domains (1) summary
      PTZ00070
      Location:54 → 273
      PTZ00070; 40S ribosomal protein S2; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14251841..14253697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269975.1 → XP_063126045.1  small ribosomal subunit protein uS5 isoform X1

      UniProtKB/Swiss-Prot
      P27952, Q4G062
      UniProtKB/TrEMBL
      E9PU05, O55215
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27952.1 GenPept UniProtKB/Swiss-Prot:P27952

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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