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    Wnt7b Wnt family member 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315196, updated on 27-Nov-2024

    Summary

    Official Symbol
    Wnt7bprovided by RGD
    Official Full Name
    Wnt family member 7Bprovided by RGD
    Primary source
    RGD:1311441
    See related
    EnsemblRapid:ENSRNOG00000015750 AllianceGenome:RGD:1311441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chemoattractant activity involved in axon guidance; cytokine activity; and frizzled binding activity. Involved in several processes, including positive regulation of JNK cascade; regulation of cell projection size; and response to glucocorticoid. Located in extracellular space. Orthologous to human WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 45.1), Kidney (RPKM 38.4) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wnt7b in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (118514684..118559316, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (116634817..116679459, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (126423418..126465724, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ataxin 10 Neighboring gene uncharacterized LOC120093705 Neighboring gene uncharacterized LOC102554082 Neighboring gene uncharacterized LOC134479761 Neighboring gene microRNA let7c-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chemoattractant activity involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anatomical structure regression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell proliferation in forebrain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within central nervous system vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemoattraction of dopaminergic neuron axon ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chorio-allantoic fusion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within developmental growth involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic placenta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in forebrain regionalization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostatic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner medullary collecting duct development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular oxygen homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lobar bronchus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung-associated mesenchyme development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mammary gland epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metanephric collecting duct development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metanephric epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metanephric loop of Henle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metanephros morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within outer medullary collecting duct development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell projection size IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within renal inner medulla development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renal outer medulla development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stem cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within trachea cartilage morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein Wnt-7b
    Names
    wingless-related MMTV integration site 7B
    wingless-type MMTV integration site family, member 7B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009695.2NP_001009695.1  protein Wnt-7b isoform 1

      See identical proteins and their annotated locations for NP_001009695.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5NSW6
      Related
      ENSRNOP00000093131.1, ENSRNOT00000108799.2
      Conserved Domains (1) summary
      cd19350
      Location:32349
      wnt_Wnt7b; Wnt domain found in protein Wnt-7b and similar proteins
    2. NM_001412610.1NP_001399539.1  protein Wnt-7b isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K3B7
      Related
      ENSRNOP00000072573.1, ENSRNOT00000081032.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      118514684..118559316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079298.1XP_038935226.1  protein Wnt-7b isoform X1

      Conserved Domains (1) summary
      cl38924
      Location:28276
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family