Slc17a1 solute carrier family 17 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc17a1provided by RGD
Official Full Name: solute carrier family 17 member 1provided by RGD
Primary source: RGD:620099
See related: EnsemblRapid:ENSRNOG00000042692 AllianceGenome:RGD:620099
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Napi-1
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in several processes, including sodium-dependent phosphate transport; urate metabolic process; and urate transport. Predicted to be active in apical plasma membrane. Orthologous to human SLC17A1 (solute carrier family 17 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 515.4) and Liver (RPKM 305.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41647332..41683078, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41219461..41255199, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43473048..43504645, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both VGluT1 and VGluT2 were expressed in axon terminals of primary afferent fibers, including SP-containing nociceptive fibers and that VGluT in unmyelinated primary afferent fibers terminating in lamina II was primarily VGluT2.
Title: Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat.
VGLUT1 and VGLUT2 transcripts are colocalized in most sensory neurons of the dorsal root ganglia, as well as in motor neurons of the ventral horn.
Title: Expression of vesicular glutamate transporters in rat lumbar spinal cord, with a note on dorsal root ganglia.
More than 80% of trigeminal ganglion neurons express vesicular glutamate transporter (VGluT)1 and VGluT2. VGluT1 is coexpressed with VGluT2 in the cell bodies and axon terminals in most trigeminal ganglion neurons.
Title: Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to coexpression.
VGLUT is localized to puncta coexpressing synaptophysin. Faint at birth, increases in subplate during first postnatal week, invades supragranular layers in second week and reaches adult pattern at P20-P30.
Title: Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex.
A high density of VGluT1-immunoreactive fibers is present in gracilis and cuneatus nuclei, a moderate density in lateral and interstitial subnuclei, and a low density in dorsolateral, ventral and intermediate subnuclei of the nucleus tractus solitarii.
Title: Localization of vesicular glutamate transporters and neuronal nitric oxide synthase in rat nucleus tractus solitarii.
VGLUT1 localization (most abundant in LIII/LIV and medial LV of sponal cord) is consistent with an origin from cutaneous and muscle mechanoreceptors and disappeared after rhizotomy.
Title: Vesicular glutamate transporters in the spinal cord, with special reference to sensory primary afferent synapses.
In the cerebellar granular layer, vesicular glutamate transporter 1 (Slc17a1) immunoreactivity is found in mossy fiber terminals and in single-axon terminals and in most brainstem precerebellar nuclei sending mossy fibers.
Title: Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:phosphate symporter activity	TAS Traceable Author Statement more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-dependent phosphate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in urate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in urate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in urate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate transport	IEA Inferred from Electronic Annotation more info
involved_in urate transport	ISO Inferred from Sequence Orthology more info
involved_in urate transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium-dependent phosphate transport protein 1

Names: Na(+)/PI cotransporter 1; renal Na(+)-dependent phosphate cotransporter 1; renal sodium-dependent phosphate transport protein 1; renal sodium-phosphate transport protein 1; sodium/phosphate cotransporter 1; solute carrier family 17 (organic anion transporter), member 1; solute carrier family 17 (sodium phosphate), member 1; solute carrier family 17 vesicular glutamate transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.