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    ATX2 Mn(2+) transporter ATX2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATX2
    Official Full Name
    Mn(2+) transporter ATX2
    Primary source
    SGD:S000005605
    Locus tag
    YOR079C
    See related
    AllianceGenome:SGD:S000005605; FungiDB:YOR079C; VEuPathDB:YOR079C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-30
    Summary
    Enables manganese ion transmembrane transporter activity. Involved in intracellular manganese ion homeostasis. Located in Golgi membrane; late endosome; and trans-Golgi network. Orthologous to human SLC39A9 (solute carrier family 39 member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATX2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (473475..474416, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rts2p Neighboring gene Bud21p Neighboring gene DNA-binding SCF ubiquitin ligase subunit DIA2 Neighboring gene triacylglycerol lipase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles. Lin SJ, et al. Mol Cell Biol, 1996 Nov. PMID 8887660, Free PMC Article
    2. Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function. García-Rodríguez N, et al. J Biol Chem, 2015 Apr 10. PMID 25713143, Free PMC Article
    3. Yeast Mn2+ transporter, Smf1p, is regulated by ubiquitin-dependent vacuolar protein sorting. Eguez L, et al. Genetics, 2004 May. PMID 15166140, Free PMC Article
    4. A nuclear role for the DEAD-box protein Dbp5 in tRNA export. Lari A, et al. Elife, 2019 Aug 27. PMID 31453808, Free PMC Article
    5. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Schuldiner M, et al. Cell, 2005 Nov 4. PMID 16269340

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables manganese ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mn(2+) transporter ATX2
    NP_014722.1
    • Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      473475..474416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183498.1 → NP_014722.1  TPA: Mn(2+) transporter ATX2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2E2, Q12067
      UniProtKB/TrEMBL
      A6ZNT1, B3LJC8, B5VRX5, C7GT36, C8ZI41, G2WMV7, N1NWX1
      Conserved Domains (1) summary
      pfam02535
      Location:4 → 306
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12067.1

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