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    Acly ATP citrate lyase [ Mus musculus (house mouse) ]

    Gene ID: 104112, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aclyprovided by MGI
    Official Full Name
    ATP citrate lyaseprovided by MGI
    Primary source
    MGI:MGI:103251
    See related
    Ensembl:ENSMUSG00000020917 AllianceGenome:MGI:103251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730098H14Rik
    Summary
    Enables ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and carboxylic acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 333.0), mammary gland adult (RPKM 298.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Acly in Genome Data Viewer
    Location:
    11 D; 11 63.47 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100367178..100418826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100476352..100528000, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like 10 Neighboring gene kelch-like 11 Neighboring gene STARR-positive B cell enhancer ABC_E3020 Neighboring gene microRNA 7116 Neighboring gene STARR-positive B cell enhancer ABC_E3021 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GGA) Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene outer dynein arm complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP citrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP citrate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP citrate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP citrate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetyl-CoA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in citrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in citrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxaloacetate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-citrate synthase
    Names
    ATP-citrate (pro-S-)-lyase
    citrate cleavage enzyme
    NP_001186225.1
    NP_598798.1
    XP_036012093.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199296.1NP_001186225.1  ATP-citrate synthase isoform 1

      See identical proteins and their annotated locations for NP_001186225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AK132755, BE623317, BX842667
      Consensus CDS
      CCDS56807.1
      UniProtKB/TrEMBL
      Q3TED3, Q3V117
      Related
      ENSMUSP00000103012.2, ENSMUST00000107389.8
      Conserved Domains (2) summary
      cl25712
      Location:1419
      SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
      cl26126
      Location:4891094
      Ligase_CoA; CoA-ligase
    2. NM_134037.3NP_598798.1  ATP-citrate synthase isoform 2

      See identical proteins and their annotated locations for NP_598798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the middle of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      BC056378, BE623317, BX842667
      Consensus CDS
      CCDS25425.1
      UniProtKB/Swiss-Prot
      Q91V92
      UniProtKB/TrEMBL
      Q3TED3
      Related
      ENSMUSP00000007131.10, ENSMUST00000007131.16
      Conserved Domains (2) summary
      cl25712
      Location:1419
      SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
      cl26126
      Location:4791084
      Ligase_CoA; CoA-ligase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100367178..100418826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156200.1XP_036012093.1  ATP-citrate synthase isoform X1

      Conserved Domains (1) summary
      PLN02522
      Location:1591
      PLN02522; ATP citrate (pro-S)-lyase