Nkx2-6 NK2 homeobox 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nkx2-6provided by MGI
Official Full Name: NK2 homeobox 6provided by MGI
Primary source: MGI:MGI:97351
See related: Ensembl:ENSMUSG00000044186 AllianceGenome:MGI:97351
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tix; Nkx2.6; tinman; Nkx-2.6
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; hypothalamus development; and tongue development. Acts upstream of or within several processes, including negative regulation of epithelial cell apoptotic process; pharyngeal system development; and positive regulation of epithelial cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and thymus. Human ortholog(s) of this gene implicated in familial atrial fibrillation and ventricular septal defect. Orthologous to human NKX2-6 (NK2 homeobox 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 35.0) See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.01 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (69409251..69412989)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (69171802..69175540)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

AV044928 (e-PCR)
- UniSTS:165912

PMC85512P1 (e-PCR)
- UniSTS:273475

Nkx2-6 (e-PCR), detects polymorphism
- UniSTS:527452

NoName (e-PCR)
- UniSTS:548219

Nkx2-6 (e-PCR), detects polymorphism
- UniSTS:536535

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in atrial cardiac muscle cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic heart tube development	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pericardium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in pharyngeal system development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tongue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventricular cardiac muscle cell development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Nkx-2.6

Names: Drosophila NK2 transcription factor related, locus 6; NK2 transcription factor related, locus 6; homeobox protein NK-2 homolog F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.