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    Gnl3 guanine nucleotide binding protein nucleolar 3 [ Mus musculus (house mouse) ]

    Gene ID: 30877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gnl3provided by MGI
    Official Full Name
    guanine nucleotide binding protein nucleolar 3provided by MGI
    Primary source
    MGI:MGI:1353651
    See related
    Ensembl:ENSMUSG00000042354 AllianceGenome:MGI:1353651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ns
    Summary
    Enables GTP binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization to chromosome, telomeric region; and stem cell division. Located in nucleolus and nucleoplasm. Is expressed in several structures, including brain ventricular layer; gut; jaw; liver lobe; and lung. Orthologous to human GNL3 (G protein nucleolar 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 33.9), liver E14.5 (RPKM 25.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gnl3 in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30734390..30741088, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31012433..31019131, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 4 Neighboring gene STARR-seq mESC enhancer starr_36312 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene ES cell cis-regulatory motif 1d Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene predicted gene, 24916 Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene polybromo 1 Neighboring gene predicted gene 5459 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency. Qu J, et al. J Cell Biol, 2012 Jun 11. PMID 22689653, Free PMC Article
    2. BAC transgenic expression efficiency: bicistronic versus ATG-fusion strategies. Lin T, et al. Genesis, 2007 Oct. PMID 17941047, Free PMC Article
    3. Nucleostemin in injury-induced liver regeneration. Shugo H, et al. Stem Cells Dev, 2012 Nov 1. PMID 22775537
    4. Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity. Ohmura M, et al. Stem Cells, 2008 Dec. PMID 18802033
    5. Differential requirement for nucleostemin in embryonic stem cell and neural stem cell viability. Nomura J, et al. Stem Cells, 2009 May. PMID 19418458

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleostemin role in the mammary tumor progression.
      Title: Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression.
    2. Nucleostemin expression participates in the preservation of the viability and integrity of embryonic stem cells.
      Title: Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
    3. nucleostemin protects hematopoietic stem cells (HSCs) from DNA damage accumulation and is required for the maintenance of HSCs.
      Title: Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.
    4. Mechanistic studies performed in mouse embryonic fibroblast cells showed that loss of nucleostemin triggers DNA damage and growth arrest independently of the p53 status or rRNA synthesis
      Title: Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells.
    5. NS plays a critical role in regeneration of both hepatic precursor cells and hepatocytes in response to liver injury.
      Title: Nucleostemin in injury-induced liver regeneration.
    6. Nucleostemin in the maintenance of ESC self-renewal, demonstrate the importance of rapid transit through G1 for this process, and expand the known classes of reprogramming factors.
      Title: Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency.
    7. NS functions downstream of Myc as a rate-limiting regulator of cell proliferation and transformation.
      Title: Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency.
    8. NS undergoes a ubiquitin- and MDM2-independent proteasomal degradation when intracellular GTP levels are markedly reduced
      Title: Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion.
    9. a complex composed of TERT, BRG1, and NS/GNL3L maintains the function of tumor initiating cells
      Title: Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.
    10. Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
      Title: Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46970

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stem cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein-like 3
    Names
    guanine nucleotide binding protein-like 3 (nucleolar)
    nucleolar GTP-binding protein 3
    nucleostemin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153547.6 → NP_705775.2  guanine nucleotide-binding protein-like 3

      See identical proteins and their annotated locations for NP_705775.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      AA041888, AK077523, CJ071960, CJ089318
      Consensus CDS
      CCDS26905.1
      UniProtKB/Swiss-Prot
      Q811R9, Q811S8, Q8BK21, Q8CI11
      UniProtKB/TrEMBL
      Q3TK27
      Related
      ENSMUSP00000047119.7, ENSMUST00000037739.8
      Conserved Domains (3) summary
      cd04178
      Location:140 → 302
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      TIGR03596
      Location:130 → 395
      GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF
      pfam08701
      Location:16 → 93
      GN3L_Grn1; GNL3L/Grn1 putative GTPase

    RNA

    1. NR_104298.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice sites at internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AA041888, AK077523, AK167094, CJ071960, CJ089318
      Related
      ENSMUST00000226740.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30734390..30741088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178846.2: Suppressed sequence

      Description
      NM_178846.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI11.2 GenPept UniProtKB/Swiss-Prot:Q8CI11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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