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    Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 54342, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gnpnat1provided by MGI
    Official Full Name
    glucosamine-phosphate N-acetyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1858963
    See related
    Ensembl:ENSMUSG00000037722 AllianceGenome:MGI:1858963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMeg32; Gpnat1; Gsnpat
    Summary
    Enables glucosamine 6-phosphate N-acetyltransferase activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and sensory organ. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.7), liver E18 (RPKM 6.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gnpnat1 in Genome Data Viewer
    Location:
    14 C1; 14 22.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45613897..45626972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45376421..45388987, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:45949463-45949646 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 Neighboring gene serine/threonine/tyrosine interaction protein Neighboring gene STARR-seq mESC enhancer starr_36535 Neighboring gene predicted gene, 41143 Neighboring gene STARR-seq mESC enhancer starr_36537 Neighboring gene predicted gene, 34250

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucosamine 6-phosphate N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucosamine 6-phosphate N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucosamine 6-phosphate N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glucosamine 6-phosphate N-acetyltransferase
    Names
    glucosamine-6-phosphate acetyltransferase
    glucosamine-phosphate N-acetyltransferase 1; glucosamine-6-phosphate acetyltransferase; glucosamine-phosphate N-acetyltransferase
    phosphoglucosamine acetylase
    phosphoglucosamine transacetylase
    NP_001404467.1
    NP_001404468.1
    NP_001404469.1
    NP_001404470.1
    NP_001404471.1
    NP_001404472.1
    NP_001404473.1
    NP_001404474.1
    NP_001404475.1
    NP_001404476.1
    NP_001404478.1
    NP_001404479.1
    NP_062298.1
    XP_036014653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417538.1NP_001404467.1  glucosamine 6-phosphate N-acetyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/TrEMBL
      A0A2I3BQY4, Q3THZ8
      Related
      ENSMUSP00000154382.2, ENSMUST00000226276.2
    2. NM_001417539.1NP_001404468.1  glucosamine 6-phosphate N-acetyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/TrEMBL
      Q3THZ8
    3. NM_001417540.1NP_001404469.1  glucosamine 6-phosphate N-acetyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/TrEMBL
      Q3THZ8
    4. NM_001417541.1NP_001404470.1  glucosamine 6-phosphate N-acetyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025535
    5. NM_001417542.1NP_001404471.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
    6. NM_001417543.1NP_001404472.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
    7. NM_001417544.1NP_001404473.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
    8. NM_001417545.1NP_001404474.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
    9. NM_001417546.1NP_001404475.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
    10. NM_001417547.1NP_001404476.1  glucosamine 6-phosphate N-acetyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/TrEMBL
      Q3THZ8
    11. NM_001417549.1NP_001404478.1  glucosamine 6-phosphate N-acetyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/TrEMBL
      A0A2I3BRZ8
      Related
      ENSMUSP00000154777.2, ENSMUST00000227865.2
    12. NM_001417550.1NP_001404479.1  glucosamine 6-phosphate N-acetyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT025535
      UniProtKB/TrEMBL
      A0A2I3BRZ8
    13. NM_019425.3NP_062298.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

      See identical proteins and their annotated locations for NP_062298.1

      Status: VALIDATED

      Source sequence(s)
      CT025535
      Consensus CDS
      CCDS26976.1
      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
      Related
      ENSMUSP00000042860.8, ENSMUST00000046191.9
      Conserved Domains (1) summary
      cl17182
      Location:36174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      45613897..45626972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158760.1XP_036014653.1  glucosamine 6-phosphate N-acetyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q9JK38
      UniProtKB/TrEMBL
      Q3THZ8
      Conserved Domains (1) summary
      cl17182
      Location:36174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate