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    Tuba1a tubulin, alpha 1A [ Mus musculus (house mouse) ]

    Gene ID: 22142, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tuba1aprovided by MGI
    Official Full Name
    tubulin, alpha 1Aprovided by MGI
    Primary source
    MGI:MGI:98869
    See related
    Ensembl:ENSMUSG00000072235 AllianceGenome:MGI:98869
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tuba1; Tuba-1
    Summary
    Enables GTP binding activity and protein heterodimerization activity. Involved in several processes, including learning or memory; microtubule cytoskeleton organization; and nervous system development. Located in cytoplasmic microtubule. Is active in several cellular components, including condensed chromosome; neuromuscular junction; and sperm flagellum. Is expressed in several structures, including brain; hemolymphoid system gland; lateral plate mesoderm; musculature; and testis. Used to study congenital nervous system abnormality and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to human TUBA1A (tubulin alpha 1a). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 4150.7), CNS E18 (RPKM 3651.9) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tuba1a in Genome Data Viewer
    Location:
    15 F1; 15 55.29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98847728..98851382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98949847..98953501, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene limb region 1 like Neighboring gene STARR-positive B cell enhancer mm9_chr15:98748573-98748874 Neighboring gene predicted gene, 41396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98764367-98764476 Neighboring gene tubulin, alpha 1B Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98783649-98783758 Neighboring gene STARR-positive B cell enhancer ABC_E7416 Neighboring gene RIKEN cDNA B430209F14 gene Neighboring gene VISTA enhancer mm1449 Neighboring gene STARR-seq mESC enhancer starr_39685 Neighboring gene RIKEN cDNA 4930578M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E10881 Neighboring gene STARR-seq mESC enhancer starr_39686

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102097, MGC102098, MGC102099

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebellar cortex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in motor behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyramidal neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to L-glutamate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axonemal microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tubulin alpha-1A chain
    Names
    Talpha1 alpha-tubulin
    alpha-tubulin 1
    alpha-tubulin isotype M-alpha-1
    tubulin alpha-1 chain
    tubulin, alpha 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011653.2NP_035783.1  tubulin alpha-1A chain

      See identical proteins and their annotated locations for NP_035783.1

      Status: PROVISIONAL

      Source sequence(s)
      AC161165
      Consensus CDS
      CCDS37196.1
      UniProtKB/Swiss-Prot
      P68369, Q3TGF0, Q3TIW2, Q3TPJ1, Q3ULN1, Q5XJF8
      UniProtKB/TrEMBL
      Q3TIZ0
      Related
      ENSMUSP00000094778.6, ENSMUST00000097014.7
      Conserved Domains (1) summary
      PTZ00335
      Location:1440
      PTZ00335; tubulin alpha chain; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98847728..98851382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)