Krt76 keratin 76 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt76provided by MGI
Official Full Name: keratin 76provided by MGI
Primary source: MGI:MGI:1924305
See related: Ensembl:ENSMUSG00000075402 AllianceGenome:MGI:1924305
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310001L23Rik
Summary: Predicted to be a structural constituent of skin epidermis. Acts upstream of or within epidermis development; pigmentation; and sebaceous gland development. Predicted to be active in keratin filament. Is expressed in several structures, including eyelid; metapodial pad; secondary palate; skin; and snout. Orthologous to human KRT76 (keratin 76). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 15 F2; 15 57.1 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101792786..101801355, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101884351..101892920, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies.
Title: K(2P)2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies.
Data shows that immunomodulatory role of Keratin 76 in oral and gastric cancer.
Title: Immunomodulatory role of Keratin 76 in oral and gastric cancer.
We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions.
Title: Keratin 76 is required for tight junction function and maintenance of the skin barrier.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sebaceous gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 2 oral

Names: K76; type-II keratin Kb9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033177.2 → NP_001028349.1 keratin, type II cytoskeletal 2 oral

See identical proteins and their annotated locations for NP_001028349.1

Status: PROVISIONAL

Source sequence(s)

AK137676

Consensus CDS

CCDS27866.1

UniProtKB/Swiss-Prot

Q3UV17

Related

ENSMUSP00000097754.2, ENSMUST00000100179.2

Conserved Domains (3) summary

pfam00038
Location:164 → 479

Filament; Intermediate filament protein

pfam15678
Location:186 → 485

SPICE; Centriole duplication and mitotic chromosome congression

pfam16208
Location:16 → 161

Keratin_2_head; Keratin type II head