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    Npff neuropeptide FF-amide peptide precursor [ Mus musculus (house mouse) ]

    Gene ID: 54615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Npffprovided by MGI
    Official Full Name
    neuropeptide FF-amide peptide precursorprovided by MGI
    Primary source
    MGI:MGI:1891708
    See related
    Ensembl:ENSMUSG00000023052 AllianceGenome:MGI:1891708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes neuropeptides involved in analgesia, cardiovascular regulation, neuroendocrine function and opiate addiction. The encoded protein is a preproprotein that undergoes further processing to generate multiple amidated peptides. [provided by RefSeq, Jul 2015]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.3), lung adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Npff in Genome Data Viewer
    Location:
    15 F3; 15 57.65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102432274..102433056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102523839..102524621, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39845 Neighboring gene predicted gene, 36331 Neighboring gene poly(rC) binding protein 2 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene TARBP2, RISC loading complex RNA binding subunit Neighboring gene activating transcription factor 7 Neighboring gene STARR-seq mESC enhancer starr_39849 Neighboring gene uncharacterized LOC105246046 Neighboring gene STARR-seq mESC enhancer starr_39850 Neighboring gene predicted gene, 25141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NPFF signalling is critical for thermosensory and dietary regulation of thermogenesis. Zhang L, et al. Neuropeptides, 2022 Dec. PMID 36155087
    2. Central NPFF signalling is critical in the regulation of glucose homeostasis. Zhang L, et al. Mol Metab, 2022 Aug. PMID 35691527, Free PMC Article
    3. Lack of neuropeptide FF signalling in mice leads to reduced repetitive behavior, altered drinking behavior, and fuel type selection. Zhang L, et al. FASEB J, 2021 Nov. PMID 34694651
    4. Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study. Sun Y, et al. Peptides, 2021 Feb. PMID 33309723
    5. Central locomotor and cognitive effects of a NPFF receptor agonist in mouse. Betourne A, et al. Peptides, 2010 Feb. PMID 19931330

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure.
      Title: Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure.
    2. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.
      Title: Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.
    3. Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord.
      Title: Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord.
    4. Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study.
      Title: Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study.
    5. we demonstrate, for the first time, that NPFFR2 positively modulates the HPA axis via hypothalamic corticotropin-releasing factor (CRF). Our finding that NPFFR2 regulates stress-dependent neural pathways advances our understanding of neuroendocrine regulation and opens new avenues for probing the functions of NPFF.
      Title: NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents.
    6. NPFF thus plays an important role in supporting healthy adipose tissue via the maintenance of metabolically beneficial adipose tissue macrophages.
      Title: Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.
    7. Down-regulation of nitric oxide (NO) synthases (NOSs) partially significantly inhibited the viability augmentation of macrophages induced by Npff, implying a nitric oxide synthases- dependent pathway is involved.
      Title: NPFF2 receptor is involved in the modulatory effects of neuropeptide FF for macrophage cell line.
    8. results demonstrate a small but complex influence of the NPFF system on mouse behavior
      Title: Central locomotor and cognitive effects of a NPFF receptor agonist in mouse.
    9. Npff reduces the expression of cocaine-induced conditioned place preference and cocaine-induce sensitization in mice.
      Title: Neuropeptide FF (NPFF) reduces the expression of cocaine-induced conditioned place preference and cocaine-induced sensitization in animals.
    10. We postulate that Oct-1, PDX1, Pit-1, MEIS and DREAM are likely transcriptional regulators of NPFF gene expression.
      Title: Identification of transcriptional regulators of neuropeptide FF gene expression.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Potential readthrough

    Included gene: Atf7

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in excitatory postsynaptic potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasopressin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pro-FMRFamide-related neuropeptide FF
    Names
    FMRFamide-related peptides

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018787.1 → NP_061257.1  pro-FMRFamide-related neuropeptide FF preproprotein

      See identical proteins and their annotated locations for NP_061257.1

      Status: REVIEWED

      Source sequence(s)
      AF148701
      Consensus CDS
      CCDS27887.1
      UniProtKB/Swiss-Prot
      Q9WVA8
      Related
      ENSMUSP00000023814.7, ENSMUST00000023814.9
      Conserved Domains (1) summary
      pfam15085
      Location:48 → 114
      NPFF; Neuropeptide FF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      102432274..102433056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033409.1: Suppressed sequence

      Description
      NR_033409.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVA8.1 GenPept UniProtKB/Swiss-Prot:Q9WVA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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