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    Gsto1 glutathione S-transferase omega 1 [ Mus musculus (house mouse) ]

    Gene ID: 14873, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gsto1provided by MGI
    Official Full Name
    glutathione S-transferase omega 1provided by MGI
    Primary source
    MGI:MGI:1342273
    See related
    Ensembl:ENSMUSG00000025068 AllianceGenome:MGI:1342273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p28; Gstx; Spg-r; Gsto-1
    Summary
    This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015]
    Expression
    Broad expression in stomach adult (RPKM 297.2), bladder adult (RPKM 158.9) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Gsto1 in Genome Data Viewer
    Location:
    19 D1; 19 40.41 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47843412..47853229)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47854973..47864790)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene microRNA 8090 Neighboring gene STARR-seq mESC enhancer starr_46371 Neighboring gene STARR-positive B cell enhancer ABC_E2529 Neighboring gene STARR-seq mESC enhancer starr_46373 Neighboring gene STARR-seq mESC enhancer starr_46374 Neighboring gene STARR-positive B cell enhancer ABC_E1529 Neighboring gene predicted gene, 30021 Neighboring gene STARR-positive B cell enhancer ABC_E1530 Neighboring gene glutathione S-transferase omega 2 Neighboring gene STARR-positive B cell enhancer ABC_E7670 Neighboring gene VISTA enhancer mm324 Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47993319-47993502

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione dehydrogenase (ascorbate) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione dehydrogenase (ascorbate) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-ascorbic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to arsenic-containing substance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione S-transferase omega-1
    Names
    Glutathione transferase omega 1 (GSTO 1-1) (p28)
    MMA(V) reductase
    S-(Phenacyl)glutathione reductase
    glutathione S-transferase omega 1-1
    glutathione-S-transferase like
    glutathione-dependent dehydroascorbate reductase
    monomethylarsonic acid reductase
    NP_034492.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010362.3NP_034492.1  glutathione S-transferase omega-1

      See identical proteins and their annotated locations for NP_034492.1

      Status: REVIEWED

      Source sequence(s)
      AC126679, AI846704, AK146834, BE860946
      Consensus CDS
      CCDS29893.1
      UniProtKB/Swiss-Prot
      O09131, Q3TH87
      Related
      ENSMUSP00000026050.8, ENSMUST00000026050.8
      Conserved Domains (3) summary
      cd03184
      Location:108228
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      COG0625
      Location:26224
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03055
      Location:594
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47843412..47853229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)