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    Bglap3 bone gamma-carboxyglutamate protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 12095, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bglap3provided by MGI
    Official Full Name
    bone gamma-carboxyglutamate protein 3provided by MGI
    Primary source
    MGI:MGI:88155
    See related
    Ensembl:ENSMUSG00000074489 AllianceGenome:MGI:88155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORG; OC-X; mOC-X; Bglap-rs1
    Summary
    Predicted to enable hydroxyapatite binding activity. Predicted to be a structural constituent of bone. Predicted to be involved in bone development and osteoblast differentiation. Predicted to be located in several cellular components, including dendrite; extracellular space; and perikaryon. Predicted to be active in extracellular region. Is expressed in several structures, including brain; cranial ganglion; foregut; musculoskeletal system; and nasal cavity epithelium. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 48.2), placenta adult (RPKM 30.7) and 2 other tissues See more
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    Genomic context

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    See Bglap3 in Genome Data Viewer
    Location:
    3 F1; 3 38.81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88275923..88280048, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88368616..88372741, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene progestin and adipoQ receptor family member VI Neighboring gene Bglap2 promoter region Neighboring gene predicted gene, 21956 Neighboring gene bone gamma-carboxyglutamate protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. Tabernero C, et al. J Virol, 1997 Jan. PMID 8985327, Free PMC Article
    2. Evidence that the mouse osteocalcin-related gene does not encode nephrocalcin. Petrucci M, et al. Nephron Exp Nephrol, 2006. PMID 16902318
    3. Preferential expression of osteocalcin-related protein mRNA in gonadal tissues of male mice. Sato M, et al. Biochem Biophys Res Commun, 1995 Oct 4. PMID 7575621
    4. Multiple copies of the bone-specific osteocalcin gene in mouse and rat. Rahman S, et al. Endocrinology, 1993 Dec. PMID 8243336
    5. Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice. Xu Z, et al. Front Physiol, 2023. PMID 37057181, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123552

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyapatite binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of bone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of bone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bone development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to vitamin K IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    osteocalcin-related protein
    Names
    bone gamma-carboxyglutamate protein, related sequence 1
    gamma-carboxyglutamic acid-containing protein 3
    nephrocalcin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305448.1 → NP_001292377.1  osteocalcin-related protein precursor

      See identical proteins and their annotated locations for NP_001292377.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AA980874, AC102388, BY414395, BY430398
      Consensus CDS
      CCDS17472.1
      UniProtKB/Swiss-Prot
      P54615, Q78H72
      Related
      ENSMUSP00000103167.2, ENSMUST00000107543.8
      Conserved Domains (1) summary
      smart00069
      Location:31 → 91
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    2. NM_001305449.1 → NP_001292378.1  osteocalcin-related protein precursor

      See identical proteins and their annotated locations for NP_001292378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AA980874, AC102388, BY414395, BY430398
      Consensus CDS
      CCDS17472.1
      UniProtKB/Swiss-Prot
      P54615, Q78H72
      Conserved Domains (1) summary
      smart00069
      Location:31 → 91
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    3. NM_001305450.1 → NP_001292379.1  osteocalcin-related protein precursor

      See identical proteins and their annotated locations for NP_001292379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AA980874, AC102388, BY414395, BY430398
      Consensus CDS
      CCDS17472.1
      UniProtKB/Swiss-Prot
      P54615, Q78H72
      Conserved Domains (1) summary
      smart00069
      Location:31 → 91
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    4. NM_031368.5 → NP_112736.3  osteocalcin-related protein precursor

      See identical proteins and their annotated locations for NP_112736.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AA016947, AA475384, AC102388, BY414395, BY430398
      Consensus CDS
      CCDS17472.1
      UniProtKB/Swiss-Prot
      P54615, Q78H72
      Related
      ENSMUSP00000074965.5, ENSMUST00000075523.11
      Conserved Domains (1) summary
      smart00069
      Location:31 → 91
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88275923..88280048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54615.1 GenPept UniProtKB/Swiss-Prot:P54615

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