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    Mllt11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [ Mus musculus (house mouse) ]

    Gene ID: 56772, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mllt11provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11provided by MGI
    Primary source
    MGI:MGI:1929671
    See related
    Ensembl:ENSMUSG00000053192 AllianceGenome:MGI:1929671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Af1q; Zfp692
    Summary
    Predicted to be involved in several processes, including apoptotic signaling pathway; positive regulation of mitochondrial depolarization; and positive regulation of release of cytochrome c from mitochondria. Located in cytoplasm. Is expressed in several structures, including gut; nervous system; nose; retina; and secondary oocyte. Orthologous to human MLLT11 (MLLT11 transcription factor 7 cofactor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 117.9), whole brain E14.5 (RPKM 86.7) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mllt11 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95125852..95139486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95218544..95229632, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitochondrial depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial depolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein AF1q
    Names
    ALL1-fused gene from chromosome 1q
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
    zinc finger protein 692

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411090.1NP_001398019.1  protein AF1q

      Status: VALIDATED

      Source sequence(s)
      AC140190
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0
      Related
      ENSMUSP00000143755.2, ENSMUST00000196025.5
    2. NM_001411091.1NP_001398020.1  protein AF1q

      Status: VALIDATED

      Source sequence(s)
      AC140190
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0
    3. NM_001411092.1NP_001398021.1  protein AF1q

      Status: VALIDATED

      Source sequence(s)
      AC140190
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0
    4. NM_019914.5NP_064298.1  protein AF1q

      Status: VALIDATED

      Source sequence(s)
      AC140190
      Consensus CDS
      CCDS38544.1
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0
      Related
      ENSMUSP00000066448.6, ENSMUST00000065482.6
      Conserved Domains (1) summary
      pfam15017
      Location:779
      WRNPLPNID; Putative WW-binding domain and destruction box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95125852..95139486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)