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    Snip1 Smad nuclear interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 76793, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Snip1provided by MGI
    Official Full Name
    Smad nuclear interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2156003
    See related
    Ensembl:ENSMUSG00000050213 AllianceGenome:MGI:2156003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410133M08Rik
    Summary
    Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction. Is active in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; gut epithelium; metanephros; and sensory organ. Orthologous to human SNIP1 (Smad nuclear interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snip1 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124960465..124967836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125066672..125074043)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38472 Neighboring gene STARR-positive B cell enhancer ABC_E7987 Neighboring gene guanine nucleotide binding protein nucleolar 2 Neighboring gene dynein, axonemal, light intermediate polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene splicing factor 3a, subunit 2 pseudogene Neighboring gene MYST/Esa1-associated factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration. Meng D, et al. Protein Cell, 2023 May 8. PMID 37027487, Free PMC Article
    2. Smad nuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation through regulation of epithelial barrier function. Shi Y, et al. Mucosal Immunol, 2018 May. PMID 29426045
    3. LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease. Chen W, et al. Int J Biol Macromol, 2024 Mar. PMID 38309408
    4. SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. Kim RH, et al. J Biol Chem, 2001 Dec 7. PMID 11567019
    5. SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development. Matsui Y, et al. Nat Commun, 2023 Aug 8. PMID 37553330, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
      Title: LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
    2. these data demonstrated a novel mechanism whereby SNIP1 regulates intestinal inflammation through modulating intestinal epithelial barrier function
      Title: Smad nuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation through regulation of epithelial barrier function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    smad nuclear-interacting protein 1
    Names
    Smad nuclear interacting protein 1 Snip1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356560.1 → NP_001343489.1  smad nuclear-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK078163, AL626775, BB636252, BE336211
      Conserved Domains (2) summary
      cd00060
      Location:150 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl28310
      Location:3 → 97
      Rho; Transcription termination factor Rho [Transcription]

    2. NM_175246.5 → NP_780455.2  smad nuclear-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_780455.2

      Status: VALIDATED

      Source sequence(s)
      AK040571, AL626775, BE336211
      Consensus CDS
      CCDS18636.1
      UniProtKB/Swiss-Prot
      Q3V106, Q8BIZ4, Q8BIZ6
      Related
      ENSMUSP00000060721.7, ENSMUST00000052183.7
      Conserved Domains (2) summary
      COG1716
      Location:262 → 353
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:245 → 360
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124960465..124967836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIZ6.1 GenPept UniProtKB/Swiss-Prot:Q8BIZ6

    Gene LinkOut

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