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    Aacs acetoacetyl-CoA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 78894, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aacsprovided by MGI
    Official Full Name
    acetoacetyl-CoA synthetaseprovided by MGI
    Primary source
    MGI:MGI:1926144
    See related
    Ensembl:ENSMUSG00000029482 AllianceGenome:MGI:1926144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SUR5; 2210408B16Rik
    Summary
    Predicted to enable acetoacetate-CoA ligase activity and medium-chain fatty acid-CoA ligase activity. Predicted to be involved in several processes, including cellular response to glucose stimulus; positive regulation of insulin secretion; and response to oleic acid. Predicted to be located in cytosol. Is expressed in alimentary system; eye; hemolymphoid system; nervous system; and urinary system. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 107.7), subcutaneous fat pad adult (RPKM 90.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Aacs in Genome Data Viewer
    Location:
    5 G1.1; 5 64.24 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125552937..125594469)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125475873..125517405)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E853 Neighboring gene Bri3 binding protein Neighboring gene STARR-positive B cell enhancer ABC_E6383 Neighboring gene STARR-positive B cell enhancer ABC_E6384 Neighboring gene predicted gene, 40325 Neighboring gene transmembrane protein 132B Neighboring gene STARR-seq mESC enhancer starr_14382 Neighboring gene predicted gene, 32811 Neighboring gene microRNA 12200

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetoacetate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetoacetate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetoacetate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables medium-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oleic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    acetoacetyl-CoA synthetase
    NP_084486.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030210.2NP_084486.1  acetoacetyl-CoA synthetase

      See identical proteins and their annotated locations for NP_084486.1

      Status: VALIDATED

      Source sequence(s)
      AC119268
      Consensus CDS
      CCDS19687.1
      UniProtKB/Swiss-Prot
      A1IG47, Q3TCL8, Q3UD39, Q9D2R0
      Related
      ENSMUSP00000031445.4, ENSMUST00000031445.5
      Conserved Domains (2) summary
      cd05943
      Location:40663
      AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)
      TIGR01217
      Location:16671
      ac_ac_CoA_syn; acetoacetyl-CoA synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      125552937..125594469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)