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    Scarb1 scavenger receptor class B, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20778, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scarb1provided by MGI
    Official Full Name
    scavenger receptor class B, member 1provided by MGI
    Primary source
    MGI:MGI:893578
    See related
    Ensembl:ENSMUSG00000037936 AllianceGenome:MGI:893578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD36; Cla1; SRBI; Srb1; Cla-1; Hdlq1; SR-B1; SR-BI; Cd36l1; Chohd1; Hlb398; mSR-BI; D5Ertd460e
    Summary
    Enables amyloid-beta binding activity; apolipoprotein binding activity; and high-density lipoprotein particle binding activity. Involved in several processes, including cholesterol homeostasis; cholesterol transport; and regulation of lipid metabolic process. Acts upstream of or within several processes, including cholesterol catabolic process; endothelial cell proliferation; and intestinal lipid absorption. Located in caveola; cell surface; and cytoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system gland; and reproductive system. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 762.6), ovary adult (RPKM 288.2) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Scarb1 in Genome Data Viewer
    Location:
    5 64.11 cM; 5 G1.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125354151..125418082, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125277087..125341094, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor co-repressor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2765 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:125586621-125586808 Neighboring gene STARR-seq mESC enhancer starr_14360 Neighboring gene STARR-positive B cell enhancer ABC_E8824 Neighboring gene STARR-seq mESC enhancer starr_14365 Neighboring gene VISTA enhancer mm1533 Neighboring gene predicted gene, 32585 Neighboring gene predicted gene, 32701 Neighboring gene STARR-seq mESC enhancer starr_14370 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:125857623-125857848 Neighboring gene predicted gene, 40323 Neighboring gene predicted gene, 40324

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables apolipoprotein A-I binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables apolipoprotein A-I binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables high-density lipoprotein particle receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-density lipoprotein particle receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipopolysaccharide immune receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide immune receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in adhesion of symbiont to host IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adhesion of symbiont to host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in androgen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol import IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol import ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in high-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intestinal lipid absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipopolysaccharide transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipopolysaccharide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagocytosis, recognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol storage ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in recognition of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in recognition of apoptotic cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in recognition of apoptotic cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phosphatidylcholine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reverse cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vitamin transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vitamin transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in caveola IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    scavenger receptor class B member 1
    Names
    HDL QTL 1
    scavenger receptor class B type I
    scavenger receptor class B1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205082.2NP_001192011.1  scavenger receptor class B member 1 isoform 2

      See identical proteins and their annotated locations for NP_001192011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC162802
      Consensus CDS
      CCDS57383.1
      UniProtKB/Swiss-Prot
      Q61009
      Related
      ENSMUSP00000107021.2, ENSMUST00000111390.8
      Conserved Domains (1) summary
      pfam01130
      Location:26447
      CD36; CD36 family
    2. NM_001205083.2NP_001192012.1  scavenger receptor class B member 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs at the 3' end compared to variant 1. This results in a frame-shift and a longer isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC162802
      Related
      ENSMUST00000148373.8
      Conserved Domains (1) summary
      pfam01130
      Location:26447
      CD36; CD36 family
    3. NM_001424492.1NP_001411421.1  scavenger receptor class B member 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162802
    4. NM_001424493.1NP_001411422.1  scavenger receptor class B member 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC162802
    5. NM_001424494.1NP_001411423.1  scavenger receptor class B member 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162802
    6. NM_001424495.1NP_001411424.1  scavenger receptor class B member 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162802
    7. NM_001424496.1NP_001411425.1  scavenger receptor class B member 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC162802
    8. NM_001424497.1NP_001411426.1  scavenger receptor class B member 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162802
    9. NM_016741.3NP_058021.1  scavenger receptor class B member 1 isoform 1

      See identical proteins and their annotated locations for NP_058021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AC162802
      Consensus CDS
      CCDS19683.1
      UniProtKB/Swiss-Prot
      D3Z2V4, Q3TZ42, Q4FK30, Q61009, Q9CWJ7
      Related
      ENSMUSP00000083242.7, ENSMUST00000086075.13
      Conserved Domains (1) summary
      pfam01130
      Location:26447
      CD36; CD36 family

    RNA

    1. NR_188757.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162802
    2. NR_188758.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162802

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      125354151..125418082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164950.1XP_036020843.1  scavenger receptor class B member 1 isoform X2

      Conserved Domains (1) summary
      pfam01130
      Location:11416
      CD36; CD36 family
    2. XM_030254308.1XP_030110168.1  scavenger receptor class B member 1 isoform X3

      Conserved Domains (1) summary
      pfam01130
      Location:1393
      CD36; CD36 family
    3. XM_017320764.2XP_017176253.1  scavenger receptor class B member 1 isoform X1

      Conserved Domains (1) summary
      pfam01130
      Location:11416
      CD36; CD36 family
    4. XM_030254309.2XP_030110169.1  scavenger receptor class B member 1 isoform X3

      Conserved Domains (1) summary
      pfam01130
      Location:1393
      CD36; CD36 family