Kif4 kinesin family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif4provided by MGI
Official Full Name: kinesin family member 4provided by MGI
Primary source: MGI:MGI:108389
See related: Ensembl:ENSMUSG00000034311 AllianceGenome:MGI:108389
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kns4; D330050K22Rik
Summary: Predicted to enable microtubule motor activity. Predicted to be involved in mitotic cytokinesis and mitotic spindle midzone assembly. Predicted to be located in midbody and nucleoplasm. Predicted to be part of microtubule associated complex. Is expressed in several structures, including alimentary system; brain; extraembryonic component; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to several human genes including KIF4A (kinesin family member 4A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 10.5), liver E14 (RPKM 7.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3; X 43.72 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (99669693..99770878)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (100626065..100727271)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.
Title: KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.
CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.
Title: CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.
Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.
Title: Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.
This work reveals essential roles for Kif4 during the meiotic divisions.
Title: Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.
KIF4 was first found in neuron, then in chromatin and later in cytoplasm. It is expressed in various types of cells including cancer cells and germ cells. KIF4 also showed dynamic changes throughout the cell cycle. It is abnormally expressed in many cancers. [review]
Title: The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
Title: Kif4 Is Essential for Mouse Oocyte Meiosis.
the silencing of Kif4 regulated VRGFR1 mRNA transcription and sVEGFR1 production in monocytes via the PI3K/Akt signaling pathway, which may be one of the mechanisms responsible for these processes.
Title: Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.
Kif4 is necessary for efficient migration of cells.
Title: Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.
Closure of the backdoor by ATP binding and hydrolysis stabilizes two mobile regions, switch I and switch II, to generate the phosphate tube from which hydrolyzed phosphate is released.
Title: Structural basis for the ATP-induced isomerization of kinesin.
KIF4 is involved in the anterograde trafficking of ribosomal constituents to axons
Title: KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI323435 (e-PCR)
- UniSTS:181312

D12646 (e-PCR)
- UniSTS:160891

Kif4 (e-PCR), detects polymorphism
- UniSTS:507009

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle midzone assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromosome-associated kinesin KIF4

Names: N-5 kinesin; chromokinesin; kinesin heavy chain member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008446.3 → NP_032472.2 chromosome-associated kinesin KIF4

See identical proteins and their annotated locations for NP_032472.2

Status: VALIDATED

Source sequence(s)

BX005480, BX276129

Consensus CDS

CCDS30305.1

UniProtKB/Swiss-Prot

P33174, Q80YP3

Related

ENSMUSP00000048383.4, ENSMUST00000048962.4

Conserved Domains (4) summary

smart00129
Location:9 → 344

KISc; Kinesin motor, catalytic domain. ATPase

COG0419
Location:407 → 995

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01372
Location:8 → 338

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam05033
Location:1070 → 1120

Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

99669693..99770878

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527855.5 → XP_006527918.1 chromosome-associated kinesin KIF4 isoform X1

Conserved Domains (3) summary

COG0419
Location:407 → 987

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01372
Location:8 → 338

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam05033
Location:1045 → 1087

Pre-SET; Pre-SET motif
XM_011247528.4 → XP_011245830.1 chromosome-associated kinesin KIF4 isoform X2

See identical proteins and their annotated locations for XP_011245830.1

Conserved Domains (3) summary

COG0419
Location:18 → 606

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

TIGR02169
Location:173 → 459

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05033
Location:689 → 731

Pre-SET; Pre-SET motif
XM_017318397.3 → XP_017173886.1 chromosome-associated kinesin KIF4 isoform X3

Conserved Domains (2) summary

COG0419
Location:44 → 518

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

pfam05033
Location:601 → 643

Pre-SET; Pre-SET motif