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    Akap14 A kinase anchor protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 434756, updated on 27-Nov-2024

    Summary

    Official Symbol
    Akap14provided by MGI
    Official Full Name
    A kinase anchor protein 14provided by MGI
    Primary source
    MGI:MGI:3618288
    See related
    Ensembl:ENSMUSG00000036551 AllianceGenome:MGI:3618288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The human ortholog of this gene has been characterized. It is reported to be enriched in airway cilia and to regulate ciliary beat frequency by anchoring the protein kinase A holoenzyme near substrates in the axoneme. [provided by RefSeq, May 2013]
    Expression
    Biased expression in whole brain E14.5 (RPKM 5.8), CNS E14 (RPKM 5.4) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Akap14 in Genome Data Viewer
    Location:
    X A3.3; X 21.57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36414351..36432495, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37150698..37168842, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 69 Neighboring gene ribosomal protein L39 Neighboring gene UPF3 regulator of nonsense transcripts homolog B (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E5721 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34666661-34666844 Neighboring gene NFKB activating protein Neighboring gene predicted gene, 39503 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34731294-34731403 Neighboring gene NADH:ubiquinone oxidoreductase subunit A1 Neighboring gene ring finger protein 113A1 Neighboring gene predicted gene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 14
    Names
    A kinase (PRKA) anchor protein 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033785.2NP_001028957.1  A-kinase anchor protein 14

      See identical proteins and their annotated locations for NP_001028957.1

      Status: REVIEWED

      Source sequence(s)
      AK133120
      Consensus CDS
      CCDS30070.1
      UniProtKB/TrEMBL
      Q3V0I7
      Related
      ENSMUSP00000048773.6, ENSMUST00000046557.6
      Conserved Domains (1) summary
      pfam14469
      Location:408528
      AKAP28; 28 kDa A-kinase anchor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      36414351..36432495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)