Aox1 aldehyde oxidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aox1provided by MGI
Official Full Name: aldehyde oxidase 1provided by MGI
Primary source: MGI:MGI:88035
See related: Ensembl:ENSMUSG00000063558 AllianceGenome:MGI:88035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ao; Ro; Aox2; Moro; Aox-1; Aox-2
Summary: Enables aldehyde oxidase activity and protein homodimerization activity. Involved in xenobiotic metabolic process. Located in cytosol. Is expressed in retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 8.7), subcutaneous fat pad adult (RPKM 8.5) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.3; 1 28.86 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (58068963..58145569)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (58029809..58106410)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
findings suggest that AOX1 acts as a contributor to the process of myogenesis by influencing the level of H2O2
Title: Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells.
only Glu1265 is essential for catalytic activity by initiating the base-catalyzed mechanism of substrate oxidation
Title: Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1.
These data indicate that AOX1 is essential for adipogenesis and may link energy and drug metabolism.
Title: Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI196512 (e-PCR)
- UniSTS:158797

Aox1 (e-PCR), detects polymorphism
- UniSTS:506730

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables aldehyde oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde oxidase activity	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin cofactor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aldehyde oxidase 1

Names: aldehyde oxidase 2; azaheterocycle hydroxylase 1; retinal oxidase

NP_033806.2

EC 1.2.3.1

XP_006495693.1

EC 1.2.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009676.2 → NP_033806.2 aldehyde oxidase 1

See identical proteins and their annotated locations for NP_033806.2

Status: VALIDATED

Source sequence(s)

AB017482, AC025116, AC117562

Consensus CDS

CCDS35575.1

UniProtKB/TrEMBL

G3X8P9, Q8R387

Related

ENSMUSP00000001027.7, ENSMUST00000001027.7

Conserved Domains (6) summary

TIGR02969
Location:5 → 1333

mam_aldehyde_ox; aldehyde oxidase

pfam00941
Location:238 → 418

FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase

pfam01315
Location:593 → 695

Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

pfam01799
Location:87 → 160

Fer2_2; [2Fe-2S] binding domain

pfam02738
Location:708 → 1240

Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase

pfam03450
Location:425 → 529

CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

58068963..58145569

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495630.5 → XP_006495693.1 aldehyde oxidase 1 isoform X1

Conserved Domains (1) summary

TIGR02969
Location:5 → 703

mam_aldehyde_ox; aldehyde oxidase