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    Atf6 activating transcription factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 226641, updated on 28-Jan-2025

    Summary

    Official Symbol
    Atf6provided by MGI
    Official Full Name
    activating transcription factor 6provided by MGI
    Primary source
    MGI:MGI:1926157
    See related
    Ensembl:ENSMUSG00000026663 AllianceGenome:MGI:1926157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM49; Atf6alpha; 9630036G24; 9130025P16Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein heterodimerization activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Used to study achromatopsia 7. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in heart adult (RPKM 10.2), genital fat pad adult (RPKM 8.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atf6 in Genome Data Viewer
    Location:
    1 H3; 1 76.96 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170532026..170696414, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170704457..170868585, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02995 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene olfactomedin-like 2B Neighboring gene predicted gene, 23523 Neighboring gene predicted gene, 25235 Neighboring gene STARR-positive B cell enhancer ABC_E4381 Neighboring gene STARR-positive B cell enhancer ABC_E7774 Neighboring gene STARR-positive B cell enhancer ABC_E7775 Neighboring gene STARR-positive B cell enhancer ABC_E5842 Neighboring gene predicted gene, 29733 Neighboring gene STARR-seq mESC enhancer starr_02996 Neighboring gene predicted gene 9929 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene dual specificity phosphatase 12 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene Fc receptor-like B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables enzyme binding  
    enables enzyme binding  
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response  
    involved_in eye development  
    involved_in eye development  
    involved_in positive regulation of ATF6-mediated unfolded protein response  
    involved_in positive regulation of ATF6-mediated unfolded protein response  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of autophagy PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to unfolded protein  
    involved_in visual perception  
    involved_in visual perception  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    cyclic AMP-dependent transcription factor ATF-6 alpha
    Names
    ATF6-alpha
    activating transcription factor 6 alpha
    cAMP-dependent transcription factor ATF-6 alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081304.1NP_001074773.1  cyclic AMP-dependent transcription factor ATF-6 alpha

      See identical proteins and their annotated locations for NP_001074773.1

      Status: VALIDATED

      Source sequence(s)
      AC113490, AC125021
      Consensus CDS
      CCDS56653.1
      UniProtKB/Swiss-Prot
      B2RU98, F6VAN0, Q8BZ84
      UniProtKB/TrEMBL
      Q811K9
      Related
      ENSMUSP00000027974.6, ENSMUST00000027974.7
      Conserved Domains (2) summary
      cd14700
      Location:296347
      bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
      pfam05817
      Location:223298
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170532026..170696414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253420.2XP_030109280.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1

      UniProtKB/Swiss-Prot
      B2RU98, F6VAN0, Q8BZ84
      UniProtKB/TrEMBL
      Q811K9
      Conserved Domains (2) summary
      cd14700
      Location:296347
      bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
      pfam05817
      Location:223298
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
    2. XM_011238796.4XP_011237098.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X2

      UniProtKB/TrEMBL
      Q811K9
      Conserved Domains (2) summary
      cd14700
      Location:296347
      bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
      pfam05817
      Location:223298
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
    3. XM_006496792.5XP_006496855.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3

      UniProtKB/TrEMBL
      Q811K9
      Conserved Domains (2) summary
      cd14700
      Location:281332
      bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
      pfam05817
      Location:208283
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
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