Slfn2 schlafen 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slfn2provided by MGI
Official Full Name: schlafen 2provided by MGI
Primary source: MGI:MGI:1313258
See related: Ensembl:ENSMUSG00000072620 AllianceGenome:MGI:1313258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Shlf2
Summary: Enables tRNA binding activity. Involved in T cell mediated immunity; T cell proliferation involved in immune response; and tRNA stabilization. Acts upstream of or within negative regulation of cell population proliferation and response to bacterium. Is active in cytoplasm. Is expressed in temporal bone. Orthologous to human SLFN12 (schlafen family member 12) and SLFN12L (schlafen family member 12 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 14.2), thymus adult (RPKM 14.1) and 18 other tissues See more
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Genomic context

Location:: 11 C; 11 50.3 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (82955938..82961504)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83065112..83070678)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells.
Title: Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells.
SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity.
Title: SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity.
Overall, these data suggest that Slfn2 is required for normal osteoclast differentiation and that loss of its function in mice results in an osteopetrotic phenotype.
Title: Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors.
we provide evidence that targeted disruption of the Slfn2 gene leads to increased transcription of IFN-stimulated genes (ISGs) and enhanced type I IFN-mediated antiviral responses
Title: Slfn2 Regulates Type I Interferon Responses by Modulating the NF-κB Pathway.
there is a functional connection between Slfn2 induced quiescence in T cells and endoplasmic reticulum homeostasis, which shows a novel mechanism by which immune cell quiescence is maintained
Title: Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence.
Regulation of cholesterol levels through the prevention of endoplasmic reticulum stress is an essential component of the mechanism by which Slfn2 regulates T-cell quiescence.
Title: Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.
several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
Title: Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.
Slfn2 completely blocked maturation of T cells but there was no difference between Slfn2 expressing and none expressing NK cells.
Title: Effect of Schlafen 2 on natural killer and T cell development from common T/natural killer progenitors.
Our findings identify a physiological role for Slfn2 in the defense against pathogens through the regulation of quiescence in T cells and monocytes.
Title: An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Slfn2 acts as a regulator of T cell quiescence
Title: Quieting T cells with Slfn2.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

D11Pas76 (e-PCR), detects polymorphism
- UniSTS:259494

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell mediated immunity	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell proliferation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in tRNA stabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: schlafen family member 2

Names: Schlafen family member 2; schlafen family member 12-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.