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    Thumpd2 THUMP domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 72167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thumpd2provided by MGI
    Official Full Name
    THUMP domain containing 2provided by MGI
    Primary source
    MGI:MGI:1919417
    See related
    Ensembl:ENSMUSG00000024246 AllianceGenome:MGI:1919417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810025A12Rik
    Summary
    Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. Orthologous to human THUMPD2 (THUMP domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Thumpd2 in Genome Data Viewer
    Location:
    17 E3; 17 51.04 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (81331676..81372542, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (81024247..81065113, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43336 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene transmembrane protein 178 Neighboring gene STARR-seq mESC enhancer starr_43337 Neighboring gene STARR-seq mESC enhancer starr_43338 Neighboring gene predicted gene, 53963 Neighboring gene STARR-seq mESC enhancer starr_43339 Neighboring gene predicted gene, 33944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    THUMP domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028138.1 → NP_082414.1  THUMP domain-containing protein 2

      See identical proteins and their annotated locations for NP_082414.1

      Status: VALIDATED

      Source sequence(s)
      AC165966, AK012806, BY133372
      Consensus CDS
      CCDS50190.1
      UniProtKB/Swiss-Prot
      Q9CZB3
      Related
      ENSMUSP00000025093.5, ENSMUST00000025093.6
      Conserved Domains (3) summary
      cd11715
      Location:18 → 76
      THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
      smart00981
      Location:203 → 264
      THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
      cl17173
      Location:274 → 419
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      81331676..81372542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246636.4 → XP_011244938.1  THUMP domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      cd11715
      Location:18 → 76
      THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
      smart00981
      Location:203 → 264
      THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
      cl17173
      Location:274 → 423
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_030250061.2 → XP_030105921.1  THUMP domain-containing protein 2 isoform X3

      Conserved Domains (2) summary
      smart00981
      Location:143 → 204
      THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
      cl17173
      Location:214 → 359
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_011246637.4 → XP_011244939.1  THUMP domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      smart00981
      Location:143 → 204
      THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
      cl17173
      Location:214 → 363
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_017317655.2 → XP_017173144.1  THUMP domain-containing protein 2 isoform X7

      Conserved Domains (1) summary
      cl17173
      Location:6 → 155
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_036160790.1 → XP_036016683.1  THUMP domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:66 → 215
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_017317656.3 → XP_017173145.1  THUMP domain-containing protein 2 isoform X8

      Conserved Domains (2) summary
      cd11715
      Location:18 → 76
      THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
      cl17173
      Location:203 → 317
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_011246639.4 → XP_011244941.1  THUMP domain-containing protein 2 isoform X4

      Conserved Domains (2) summary
      cd11715
      Location:18 → 76
      THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
      cl17173
      Location:203 → 364
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    8. XM_036160791.1 → XP_036016684.1  THUMP domain-containing protein 2 isoform X6

      Conserved Domains (2) summary
      cd11715
      Location:18 → 76
      THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
      smart00981
      Location:203 → 264
      THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs

    RNA

    1. XR_003952188.2 RNA Sequence

    2. XR_001782115.3 RNA Sequence

    3. XR_876548.3 RNA Sequence

    4. XR_001782116.3 RNA Sequence

    5. XR_004939583.1 RNA Sequence

    6. XR_003952189.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZB3.3 GenPept UniProtKB/Swiss-Prot:Q9CZB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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