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    Icosl icos ligand [ Mus musculus (house mouse) ]

    Gene ID: 50723, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Icoslprovided by MGI
    Official Full Name
    icos ligandprovided by MGI
    Primary source
    MGI:MGI:1354701
    See related
    Ensembl:ENSMUSG00000000732 AllianceGenome:MGI:1354701
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B7h; GI50; GL50; B7-H2; LICOS; B7RP-1; GL50-B; ICOS-L; Icoslg; Ly115l; mKIAA0653
    Summary
    Predicted to enable identical protein binding activity and signaling receptor binding activity. Involved in positive regulation of interleukin-4 production. Located in external side of plasma membrane. Is expressed in several structures, including extraembryonic component; gonad; hemolymphoid system gland; liver; and stomach. Orthologous to human ICOSLG (inducible T cell costimulator ligand). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 32.9), mammary gland adult (RPKM 16.0) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Icosl in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77904921..77915359)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78069368..78079525)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphofructokinase, liver, B-type Neighboring gene STARR-positive B cell enhancer ABC_E5151 Neighboring gene STARR-seq mESC enhancer starr_27212 Neighboring gene STARR-seq mESC enhancer starr_27213 Neighboring gene STARR-seq mESC enhancer starr_27214 Neighboring gene STARR-seq mESC enhancer starr_27215 Neighboring gene autoimmune regulator Neighboring gene DNA methyltransferase 3-like Neighboring gene predicted gene, 51775 Neighboring gene STARR-positive B cell enhancer ABC_E5152 Neighboring gene STARR-positive B cell enhancer ABC_E6876 Neighboring gene STARR-positive B cell enhancer ABC_E2328 Neighboring gene predicted gene, 47922 Neighboring gene glutamine amidotransferase like class 1 domain containing 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. Hu YL, et al. J Immunol, 2009 Feb 1. PMID 19155489
    2. Effects of ICOSLG expressed in mouse hematological neoplasm cell lines in the GVL reaction. Wang B, et al. Bone Marrow Transplant, 2013 Jan. PMID 22732700
    3. B cell-specific expression of inducible costimulator ligand is necessary for the induction of arthritis in mice. Hamel KM, et al. Arthritis Rheumatol, 2014 Jan. PMID 24449576
    4. B7h-expressing dendritic cells and plasma B cells mediate distinct outcomes of ICOS costimulation in T cell-dependent antibody responses. Larimore K, et al. BMC Immunol, 2012 Jun 11. PMID 22686515, Free PMC Article
    5. Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. Chen X, et al. PLoS Pathog, 2014 May. PMID 24788758, Free PMC Article

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The impact of ICOSL/ICOS pathway-regulated long non-coding RNAs on liver fibrosis in mice infected with Schistosoma japonicum.
      Title: The impact of ICOSL/ICOS pathway-regulated long non-coding RNAs on liver fibrosis in mice infected with Schistosoma japonicum.
    2. MiR-155-targeted IcosL controls tumor rejection.
      Title: MiR-155-targeted IcosL controls tumor rejection.
    3. A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
      Title: A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
    4. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
      Title: Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
    5. Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
      Title: Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
    6. ICOS ligand and IL-10 synergize to promote host-microbiota mutualism.
      Title: ICOS ligand and IL-10 synergize to promote host-microbiota mutualism.
    7. work identified a potentially novel role for ICOSL, which serves as an endogenous alphavbeta3-selective antagonist to maintain glomerular filtration.
      Title: Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist.
    8. study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels
      Title: ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
    9. results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h during their differentiation, and that B7h triggering reversibly inhibits OC differentiation and function both in vitro and in vivo
      Title: ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo.
    10. study concludse that lymphopenia-driven autoimmunity and the development of Tfh17 cells in Rasgrp1-deficient mice occur independently of CD275(B7-H2)
      Title: CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice.
    Submit: New GeneRIF Correction See all GeneRIFs (57)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0653

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isotype switching NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of activated T cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ICOS ligand
    Names
    B7 homolog 2
    B7-like protein Gl50
    B7-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015790.3 → NP_056605.1  ICOS ligand precursor

      See identical proteins and their annotated locations for NP_056605.1

      Status: PROVISIONAL

      Source sequence(s)
      AC153507
      Consensus CDS
      CCDS35956.1
      UniProtKB/Swiss-Prot
      Q9JHJ8
      UniProtKB/TrEMBL
      A0A1W2P6Q2, Q544C7
      Related
      ENSMUSP00000101032.2, ENSMUST00000105393.3
      Conserved Domains (2) summary
      smart00410
      Location:52 → 140
      IG_like; Immunoglobulin like
      cl11960
      Location:166 → 253
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77904921..77915359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155889.1 → XP_036011782.1  ICOS ligand isoform X1

      Conserved Domains (3) summary
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cd20935
      Location:123 → 236
      IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)
      cl11960
      Location:241 → 328
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHJ8.1 GenPept UniProtKB/Swiss-Prot:Q9JHJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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