Aqp9 aquaporin 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aqp9provided by MGI
Official Full Name: aquaporin 9provided by MGI
Primary source: MGI:MGI:1891066
See related: Ensembl:ENSMUSG00000032204 AllianceGenome:MGI:1891066
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AQP-9; 1700020I22Rik
Summary: This gene encodes a member of the aquaglyceroporin subfamily of aquaporins. This protein transports water, glycerol, urea, purines and pyrimidines and plays a role in glycerol metabolism and osteoclast differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression: Biased expression in liver adult (RPKM 30.0), liver E18 (RPKM 8.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 39.85 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (71017941..71075170, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (71110659..71167849, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sex-specific effect of AQP9 deficiency on hepatic triglyceride metabolism in mice with diet-induced obesity.
Title: Sex-specific effect of AQP9 deficiency on hepatic triglyceride metabolism in mice with diet-induced obesity.
Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.
Title: Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.
Aquaporin 9 causes recurrent spontaneous abortion by inhibiting trophoblast cell epithelial-mesenchymal transformation and invasion through the PI3K/AKT pathwaydagger.
Title: Aquaporin 9 causes recurrent spontaneous abortion by inhibiting trophoblast cell epithelial-mesenchymal transformation and invasion through the PI3K/AKT pathway†.
Effects of Elevated Intraocular Pressure on Retinal Ganglion Cell Density and Expression and Interaction of Retinal Aquaporin 9 and Monocarboxylate Transporters.
Title: Effects of Elevated Intraocular Pressure on Retinal Ganglion Cell Density and Expression and Interaction of Retinal Aquaporin 9 and Monocarboxylate Transporters.
Integrated multiomics analysis reveals changes in liver physiological function in Aqp9 gene knockout mice.
Title: Integrated multiomics analysis reveals changes in liver physiological function in Aqp9 gene knockout mice.
Aquaporin-9 in the Brain Inflammatory Response: Evidence from Mice Injected with the Parkinsonogenic Toxin MPP.
Title: Aquaporin-9 in the Brain Inflammatory Response: Evidence from Mice Injected with the Parkinsonogenic Toxin MPP().
miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9.
Title: miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9.
Untargeted metabolomics reveals the role of AQP9 in nonalcoholic fatty liver disease in a mice model.
Title: Untargeted metabolomics reveals the role of AQP9 in nonalcoholic fatty liver disease in a mice model.
Aquaporin-9 facilitates liver regeneration following hepatectomy.
Title: Aquaporin-9 facilitates liver regeneration following hepatectomy.
Ablation of Aquaporin-9 Ameliorates the Systemic Inflammatory Response of LPS-Induced Endotoxic Shock in Mouse.
Title: Ablation of Aquaporin-9 Ameliorates the Systemic Inflammatory Response of LPS-Induced Endotoxic Shock in Mouse.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Aqp9 (e-PCR), detects polymorphism
- UniSTS:545895

Aqp9 (e-PCR), detects polymorphism
- UniSTS:186498

AI266899 (e-PCR)
- UniSTS:159893

NoName (e-PCR)
- UniSTS:236182

Aqp9 (e-PCR), detects polymorphism
- UniSTS:209570

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables channel activity	IDA Inferred from Direct Assay more info
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol channel activity	ISO Inferred from Sequence Orthology more info
enables glycerol channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrogen peroxide channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables polyol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables polyol transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables purine nucleobase transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleobase transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrimidine nucleobase transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine nucleobase transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables urea channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables urea channel activity	ISO Inferred from Sequence Orthology more info
enables urea transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urea transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urea transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in amine transport	ISO Inferred from Sequence Orthology more info
involved_in amine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in canalicular bile acid transport	ISO Inferred from Sequence Orthology more info
involved_in detoxification of arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in hydrogen peroxide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in polyol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in polyol transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleobase transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyrimidine nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyrimidine-containing compound transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to pain	ISO Inferred from Sequence Orthology more info
involved_in urea transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in urea transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within water transport	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: aquaporin-9

Names: aquaglyceroporin-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271843.1 → NP_001258772.1 aquaporin-9 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.

Source sequence(s)

AC098716

Consensus CDS

CCDS72270.1

UniProtKB/TrEMBL

D3YYD6

Related

ENSMUSP00000050127.6, ENSMUST00000060917.12

Conserved Domains (1) summary

cl00200
Location:61 → 292

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_022026.3 → NP_071309.1 aquaporin-9 isoform 1

See identical proteins and their annotated locations for NP_071309.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AI789806, AK050042

Consensus CDS

CCDS23325.1

UniProtKB/Swiss-Prot

Q9JJJ3

UniProtKB/TrEMBL

Q4FK77

Related

ENSMUSP00000074063.3, ENSMUST00000074465.9

Conserved Domains (1) summary

cl00200
Location:24 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RNA

NR_073483.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC098716

Related

ENSMUST00000144618.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

71017941..71075170 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242783.3 → XP_011241085.1 aquaporin-9 isoform X1

See identical proteins and their annotated locations for XP_011241085.1

UniProtKB/Swiss-Prot

Q9JJJ3

UniProtKB/TrEMBL

Q4FK77

Conserved Domains (1) summary

cl00200
Location:24 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_006511331.3 → XP_006511394.1 aquaporin-9 isoform X1

See identical proteins and their annotated locations for XP_006511394.1

UniProtKB/Swiss-Prot

Q9JJJ3

UniProtKB/TrEMBL

Q4FK77

Conserved Domains (1) summary

cl00200
Location:24 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_036155169.1 → XP_036011062.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

Q9JJJ3

UniProtKB/TrEMBL

Q4FK77

Related

ENSMUSP00000109200.2, ENSMUST00000113570.8

Conserved Domains (1) summary

cl00200
Location:24 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_011242782.4 → XP_011241084.1 aquaporin-9 isoform X1

See identical proteins and their annotated locations for XP_011241084.1

UniProtKB/Swiss-Prot

Q9JJJ3

UniProtKB/TrEMBL

Q4FK77

Conserved Domains (1) summary

cl00200
Location:24 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_006511332.5 → XP_006511395.1 aquaporin-9 isoform X1

See identical proteins and their annotated locations for XP_006511395.1

UniProtKB/Swiss-Prot

Q9JJJ3

UniProtKB/TrEMBL

Q4FK77

Conserved Domains (1) summary

cl00200
Location:24 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...