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    Vmn2r53 vomeronasal 2, receptor 53 [ Mus musculus (house mouse) ]

    Gene ID: 637908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vmn2r53provided by MGI
    Official Full Name
    vomeronasal 2, receptor 53provided by MGI
    Primary source
    MGI:MGI:3644480
    See related
    Ensembl:ENSMUSG00000096002 AllianceGenome:MGI:3644480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm471; EG637908
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Vmn2r53 in Genome Data Viewer
    Location:
    7 A1; 7 7.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12315397..12342583, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12581470..12606544, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18051 Neighboring gene zinc finger protein 606 Neighboring gene RIKEN cDNA 2900092C05 gene Neighboring gene STARR-seq mESC enhancer starr_18052 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18053 Neighboring gene PC4 and SFRS1 interacting protein 1 pseudogene Neighboring gene vomeronasal 2, receptor 54 Neighboring gene vomeronasal 2, receptor 55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A single vomeronasal receptor promotes intermale aggression through dedicated hypothalamic neurons. Itakura T, et al. Neuron, 2022 Aug 3. PMID 35654036
    2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    3. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal 2, receptor 53
    Names
    vomeronasal receptor Vmn2r53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104644.2 → NP_001098114.2  vomeronasal 2, receptor 53 precursor

      Status: VALIDATED

      Source sequence(s)
      AC139131
      Consensus CDS
      CCDS52018.1
      UniProtKB/TrEMBL
      A0A3B2W4A7, L7N473
      Related
      ENSMUSP00000156838.2, ENSMUST00000233892.2
      Conserved Domains (4) summary
      cd06365
      Location:41 → 493
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:514 → 567
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd14964
      Location:624 → 645
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:610 → 838
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12315397..12342583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153322.1 → XP_036009215.1  vomeronasal 2, receptor 53 isoform X1

      UniProtKB/TrEMBL
      L7N473
      Conserved Domains (4) summary
      cd06365
      Location:41 → 493
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:505 → 558
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd14964
      Location:615 → 636
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:601 → 829
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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