Pierce1 piercer of microtubule wall 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pierce1provided by MGI
Official Full Name: piercer of microtubule wall 1provided by MGI
Primary source: MGI:MGI:1916577
See related: Ensembl:ENSMUSG00000026831 AllianceGenome:MGI:1916577
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rbest47; 1700007K13Rik
Summary: Involved in axoneme assembly; establishment of left/right asymmetry; and flagellated sperm motility. Acts upstream of or within DNA damage response; cellular response to UV-C; and regulation of gene expression. Located in cytoplasm and nucleus. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in brain; genitourinary system; lung; node; and retina. Orthologous to human PIERCE1 (piercer of microtubule wall 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 17.2), lung adult (RPKM 3.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (28352013..28356336, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (28462001..28466324, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of PIERCE1 on colorectal cancer.
Title: Effect of PIERCE1 on colorectal cancer.
Divergence of the PIERCE1 expression between mice and humans as a p53 target gene.
Title: Divergence of the PIERCE1 expression between mice and humans as a p53 target gene.
This is the first report implicating a role for PIERCE1 in the symmetry-breaking step of left-right asymmetry specification.
Title: PIERCE1 is critical for specification of left-right asymmetry in mice.
RbEST47 was considerably down-regulated in immortalized cells, and showed cell cycle-dependent expression, suggesting important roles in S and/or G2[RbEST47]
Title: Identification of a novel Rb-regulated gene associated with the cell cycle.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to UV-C	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: piercer of microtubule wall 1 protein

Names: UPF0691 protein C9orf116 homolog; p53-induced expression in RB-null cells protein 1; pierce 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.