Gatad2b GATA zinc finger domain containing 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gatad2bprovided by MGI
Official Full Name: GATA zinc finger domain containing 2Bprovided by MGI
Primary source: MGI:MGI:2443225
See related: Ensembl:ENSMUSG00000042390 AllianceGenome:MGI:2443225
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P66beta; mKIAA1150; C430014D17Rik
Summary: Predicted to enable sequence-specific DNA binding activity and zinc ion binding activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of NuRD complex. Is expressed in early conceptus and genitourinary system. Used to study GAND syndrome. Human ortholog(s) of this gene implicated in GAND syndrome. Orthologous to human GATAD2B (GATA zinc finger domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 10.2), CNS E14 (RPKM 8.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.21 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90200488..90270712)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90293181..90363405)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GATAD2B is required for pre-implantation embryonic development by regulating zygotic genome activation.
Title: GATAD2B is required for pre-implantation embryonic development by regulating zygotic genome activation.
Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning.
Title: Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning.
GATAD2B interacts with C-MYC to enhance KRAS driven tumor growth.
Title: In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235288

D3Mit232 (e-PCR), detects polymorphism
- UniSTS:129652

NoName (e-PCR)
- UniSTS:234744

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell fate specification	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NuRD complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcriptional repressor p66-beta

Names: GATA zinc finger domain-containing protein 2B; p66/p68; transcription repressor p66 beta component of the MeCP1 complex; transcription repressor p66 component of the MeCP1 complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379655.1 → NP_001366584.1 transcriptional repressor p66-beta isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).

Source sequence(s)

AC119825, AC145082

UniProtKB/Swiss-Prot

Q8C9Q3, Q8VHR5

UniProtKB/TrEMBL

A1L3S7

Conserved Domains (2) summary

pfam00320
Location:421 → 455

GATA; GATA zinc finger

pfam16563
Location:161 → 195

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
NM_001379656.1 → NP_001366585.1 transcriptional repressor p66-beta isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longer isoform (a).

Source sequence(s)

AC119825, AC145082

UniProtKB/Swiss-Prot

Q8C9Q3, Q8VHR5

UniProtKB/TrEMBL

A1L3S7

Related

ENSMUSP00000142617.2, ENSMUST00000199607.5

Conserved Domains (2) summary

pfam00320
Location:421 → 455

GATA; GATA zinc finger

pfam16563
Location:161 → 195

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
NM_001379657.1 → NP_001366586.1 transcriptional repressor p66-beta isoform b

Status: VALIDATED

Source sequence(s)

AC119825, AC145082

UniProtKB/TrEMBL

A1L3S7

Conserved Domains (2) summary

pfam00320
Location:420 → 454

GATA; GATA zinc finger

pfam16563
Location:161 → 195

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
NM_139304.3 → NP_647465.1 transcriptional repressor p66-beta isoform a

See identical proteins and their annotated locations for NP_647465.1

Status: VALIDATED

Description

Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longer isoform (a).

Source sequence(s)

AC119825, AC145082

Consensus CDS

CCDS17526.1

UniProtKB/Swiss-Prot

Q8C9Q3, Q8VHR5

UniProtKB/TrEMBL

A1L3S7

Related

ENSMUSP00000142514.2, ENSMUST00000199754.5

Conserved Domains (2) summary

pfam00320
Location:421 → 455

GATA; GATA zinc finger

pfam16563
Location:161 → 195

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90200488..90270712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501360.5 → XP_006501423.3 transcriptional repressor p66-beta isoform X2

UniProtKB/TrEMBL

A1L3S7

Conserved Domains (2) summary

pfam00320
Location:497 → 530

GATA; GATA zinc finger

pfam16563
Location:238 → 272

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
XM_006501359.5 → XP_006501422.3 transcriptional repressor p66-beta isoform X1

UniProtKB/TrEMBL

A1L3S7

Conserved Domains (2) summary

pfam00320
Location:498 → 531

GATA; GATA zinc finger

pfam16563
Location:238 → 272

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
XM_036163055.1 → XP_036018948.1 transcriptional repressor p66-beta isoform X3

UniProtKB/Swiss-Prot

Q8C9Q3, Q8VHR5

UniProtKB/TrEMBL

A1L3S7

Conserved Domains (2) summary

pfam00320
Location:421 → 455

GATA; GATA zinc finger

pfam16563
Location:161 → 195

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2