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    Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Mus musculus (house mouse) ]

    Gene ID: 22195, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ube2l3provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2L 3provided by MGI
    Primary source
    MGI:MGI:109240
    See related
    Ensembl:ENSMUSG00000038965 AllianceGenome:MGI:109240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UbcM4; Ubce7
    Summary
    Enables ubiquitin conjugating enzyme activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; heart; immune system; lung; and reproductive system. Orthologous to human UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 45.0), liver E14 (RPKM 37.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube2l3 in Genome Data Viewer
    Location:
    16 A3; 16 10.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16969879..17019363, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17152015..17201512, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Rps20 pseudogene Neighboring gene coiled-coil domain containing 116 Neighboring gene STARR-positive B cell enhancer ABC_E4157 Neighboring gene YdjC homolog (bacterial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129 Neighboring gene RIMS binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Transgenic (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118100

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell cycle phase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucocorticoid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to steroid hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 L3
    Names
    E2 ubiquitin-conjugating enzyme L3
    ubiquitin carrier protein L3
    ubiquitin-conjugating enzyme 7
    ubiquitin-protein ligase L3
    NP_001406151.1
    NP_001406152.1
    NP_001406153.1
    NP_001406154.1
    NP_001406155.1
    NP_001406156.1
    NP_001406158.1
    NP_033482.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419222.1NP_001406151.1  ubiquitin-conjugating enzyme E2 L3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154667
    2. NM_001419223.1NP_001406152.1  ubiquitin-conjugating enzyme E2 L3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Related
      ENSMUSP00000156283.2, ENSMUST00000232668.2
    3. NM_001419224.1NP_001406153.1  ubiquitin-conjugating enzyme E2 L3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154667
    4. NM_001419225.1NP_001406154.1  ubiquitin-conjugating enzyme E2 L3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154667
    5. NM_001419226.1NP_001406155.1  ubiquitin-conjugating enzyme E2 L3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154667
      UniProtKB/TrEMBL
      A0A338P7E5
      Related
      ENSMUSP00000156336.2, ENSMUST00000231643.2
    6. NM_001419227.1NP_001406156.1  ubiquitin-conjugating enzyme E2 L3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154667
    7. NM_001419229.1NP_001406158.1  ubiquitin-conjugating enzyme E2 L3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Related
      ENSMUSP00000156034.2, ENSMUST00000232035.2
    8. NM_009456.3NP_033482.1  ubiquitin-conjugating enzyme E2 L3 isoform 1

      See identical proteins and their annotated locations for NP_033482.1

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Consensus CDS
      CCDS27997.1
      UniProtKB/Swiss-Prot
      P68037
      UniProtKB/TrEMBL
      Q3TIH9, Q561N4
      Related
      ENSMUSP00000087658.6, ENSMUST00000090192.12
      Conserved Domains (1) summary
      smart00212
      Location:6149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RNA

    1. NR_185043.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667
    2. NR_185044.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667
    3. NR_185045.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667
    4. NR_185046.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667
    5. NR_185047.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16969879..17019363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)