Rasal3 RAS protein activator like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasal3provided by MGI
Official Full Name: RAS protein activator like 3provided by MGI
Primary source: MGI:MGI:2444128
See related: Ensembl:ENSMUSG00000052142 AllianceGenome:MGI:2444128
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A430107D22Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and positive regulation of NK T cell proliferation. Predicted to be located in cytoplasm and cytoplasmic side of membrane. Is expressed in thymus primordium. Orthologous to human RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 113.1), spleen adult (RPKM 50.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.55 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (32609633..32622586, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32390659..32403582, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
Title: CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.
Title: RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.
Collectively, Rasal3 controls the magnitude of inflammatory responses through the survival of both naive T cells and activated T cells in vivo.
Title: Rasal3-mediated T cell survival is essential for inflammatory responses.
Rasal3 is required for in vivo survival of peripheral naive T cells, contributing to the maintenance of optimal T cell numbers.
Title: The Ras GTPase-activating protein Rasal3 supports survival of naive T cells.
results suggest that RASAL3 plays an important role in the expansion and functions of NKT cells in the liver by negatively regulating Ras/Erk signaling
Title: RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

01.MHAa56e1.seq (e-PCR)
- UniSTS:122643

BB240897 (e-PCR)
- UniSTS:209292

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RAS protein activator like-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347343.2 → NP_001334272.1 RAS protein activator like-3 isoform 1

Status: VALIDATED

Source sequence(s)

CT485616

Consensus CDS

CCDS84292.1

UniProtKB/TrEMBL

Q6KAS9

Related

ENSMUSP00000123141.2, ENSMUST00000137458.2
NM_001374604.1 → NP_001361533.1 RAS protein activator like-3 isoform 3

Status: VALIDATED

Source sequence(s)

CT485616

UniProtKB/TrEMBL

D3Z6Z7, Q6KAS9

Related

ENSMUSP00000116107.2, ENSMUST00000135618.8

Conserved Domains (3) summary

cd05136
Location:424 → 747

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

cl14603
Location:300 → 432

C2; C2 domain

cl17171
Location:181 → 326

PH-like; Pleckstrin homology-like domain
NM_001400382.1 → NP_001387311.1 RAS protein activator like-3 isoform 4

Status: VALIDATED

Source sequence(s)

CT485616
NM_178785.5 → NP_848900.2 RAS protein activator like-3 isoform 2

See identical proteins and their annotated locations for NP_848900.2

Status: VALIDATED

Source sequence(s)

CT485616

Consensus CDS

CCDS37556.1

UniProtKB/Swiss-Prot

A3KMM0, Q8C2A5, Q8C2K5, Q8C9R4, Q8CDB4

UniProtKB/TrEMBL

Q6KAS9

Related

ENSMUSP00000064084.8, ENSMUST00000063824.14

Conserved Domains (3) summary

cd05136
Location:446 → 769

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

cl14603
Location:322 → 454

C2; C2 domain

cl17171
Location:203 → 348

PH-like; Pleckstrin homology-like domain

RNA

NR_153797.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT485616
NR_174479.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT485616
NR_174480.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT485616

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

32609633..32622586 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524412.5 → XP_006524475.1 RAS protein activator like-3 isoform X1

UniProtKB/TrEMBL

Q6KAS9

Conserved Domains (3) summary

cd05136
Location:470 → 793

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

cl14603
Location:346 → 478

C2; C2 domain

cl17171
Location:227 → 372

PH-like; Pleckstrin homology-like domain
XM_030249844.2 → XP_030105704.1 RAS protein activator like-3 isoform X3

UniProtKB/TrEMBL

A0A0R4J1U7

Related

ENSMUSP00000118738.2, ENSMUST00000136375.8

Conserved Domains (3) summary

cl02569
Location:446 → 600

RasGAP; Ras GTPase Activating Domain

cl14603
Location:322 → 454

C2; C2 domain

cl17171
Location:203 → 348

PH-like; Pleckstrin homology-like domain
XM_011246497.3 → XP_011244799.1 RAS protein activator like-3 isoform X2

UniProtKB/TrEMBL

A0A0R4J1U7

Conserved Domains (3) summary

cl02569
Location:470 → 624

RasGAP; Ras GTPase Activating Domain

cl14603
Location:346 → 478

C2; C2 domain

cl17171
Location:227 → 372

PH-like; Pleckstrin homology-like domain