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    Ccdc141 coiled-coil domain containing 141 [ Mus musculus (house mouse) ]

    Gene ID: 545428, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccdc141provided by MGI
    Official Full Name
    coiled-coil domain containing 141provided by MGI
    Primary source
    MGI:MGI:1919735
    See related
    Ensembl:ENSMUSG00000044033 AllianceGenome:MGI:1919735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAMDI; 2610301F02Rik
    Summary
    Involved in brain development. Acts upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Located in centrosome and cytoplasm. Is expressed in several structures, including brain; foregut; reproductive system; respiratory system; and trigeminal nerve. Orthologous to human CCDC141 (coiled-coil domain containing 141). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 8.9), lung adult (RPKM 4.1) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ccdc141 in Genome Data Viewer
    Location:
    2 C3; 2 45.38 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76840246..77006424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (77009902..77173769, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04894 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 Neighboring gene predicted gene, 57692 Neighboring gene titin Neighboring gene STARR-seq mESC enhancer starr_04895 Neighboring gene STARR-seq mESC enhancer starr_04897 Neighboring gene STARR-seq mESC enhancer starr_04899 Neighboring gene STARR-seq mESC enhancer starr_04900 Neighboring gene STARR-seq mESC enhancer starr_04901 Neighboring gene predicted gene, 39861 Neighboring gene SEC14 and spectrin domains 1 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 35266

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 141
    Names
    coiled-coil protein associated with myosin II and DISC1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025576.3NP_001020747.2  coiled-coil domain-containing protein 141

      See identical proteins and their annotated locations for NP_001020747.2

      Status: VALIDATED

      Source sequence(s)
      AK045498, AK053175, AK084521, AL928681, BB637559
      Consensus CDS
      CCDS38155.2
      UniProtKB/Swiss-Prot
      A2AST1, E9Q8Q6
      Related
      ENSMUSP00000128736.3, ENSMUST00000164114.9
      Conserved Domains (4) summary
      TIGR00618
      Location:219790
      sbcc; exonuclease SbcC
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02169
      Location:712999
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam07679
      Location:14101499
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76840246..77006424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499911.5XP_006499974.1  coiled-coil domain-containing protein 141 isoform X1

      See identical proteins and their annotated locations for XP_006499974.1

      UniProtKB/Swiss-Prot
      A2AST1, E9Q8Q6
      Conserved Domains (4) summary
      TIGR00618
      Location:219790
      sbcc; exonuclease SbcC
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02169
      Location:712999
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam07679
      Location:14101499
      I-set; Immunoglobulin I-set domain
    2. XM_006499914.5XP_006499977.1  coiled-coil domain-containing protein 141 isoform X1

      See identical proteins and their annotated locations for XP_006499977.1

      UniProtKB/Swiss-Prot
      A2AST1, E9Q8Q6
      Conserved Domains (4) summary
      TIGR00618
      Location:219790
      sbcc; exonuclease SbcC
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02169
      Location:712999
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam07679
      Location:14101499
      I-set; Immunoglobulin I-set domain
    3. XM_006499916.5XP_006499979.1  coiled-coil domain-containing protein 141 isoform X4

      Conserved Domains (3) summary
      COG1340
      Location:8001057
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      TIGR02168
      Location:79902
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07679
      Location:13451434
      I-set; Immunoglobulin I-set domain
    4. XM_036162401.1XP_036018294.1  coiled-coil domain-containing protein 141 isoform X5

      Conserved Domains (5) summary
      COG1196
      Location:158890
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG1340
      Location:7631020
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:13081397
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:13081310
      Ig; Ig strand A [structural motif]
    5. XM_036162399.1XP_036018292.1  coiled-coil domain-containing protein 141 isoform X2

      Conserved Domains (6) summary
      COG1196
      Location:693950
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG1340
      Location:8231080
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      PRK03918
      Location:369949
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:13681457
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:13681370
      Ig; Ig strand A [structural motif]
    6. XM_036162400.1XP_036018293.1  coiled-coil domain-containing protein 141 isoform X3

      Conserved Domains (5) summary
      TIGR00618
      Location:219790
      sbcc; exonuclease SbcC
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:7161067
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07679
      Location:13601449
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:13601362
      Ig; Ig strand A [structural motif]
    7. XM_006499913.5XP_006499976.1  coiled-coil domain-containing protein 141 isoform X1

      See identical proteins and their annotated locations for XP_006499976.1

      UniProtKB/Swiss-Prot
      A2AST1, E9Q8Q6
      Conserved Domains (4) summary
      TIGR00618
      Location:219790
      sbcc; exonuclease SbcC
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02169
      Location:712999
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam07679
      Location:14101499
      I-set; Immunoglobulin I-set domain
    8. XM_006499912.4XP_006499975.1  coiled-coil domain-containing protein 141 isoform X1

      See identical proteins and their annotated locations for XP_006499975.1

      UniProtKB/Swiss-Prot
      A2AST1, E9Q8Q6
      Conserved Domains (4) summary
      TIGR00618
      Location:219790
      sbcc; exonuclease SbcC
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02169
      Location:712999
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam07679
      Location:14101499
      I-set; Immunoglobulin I-set domain
    9. XM_036162402.1XP_036018295.1  coiled-coil domain-containing protein 141 isoform X7

      Conserved Domains (3) summary
      TIGR02169
      Location:282569
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam07679
      Location:9801069
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:980982
      Ig; Ig strand A [structural motif]
    10. XM_006499917.5XP_006499980.1  coiled-coil domain-containing protein 141 isoform X6

      Conserved Domains (2) summary
      TIGR02169
      Location:712999
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl02488
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    11. XM_017319133.3XP_017174622.1  coiled-coil domain-containing protein 141 isoform X8

      UniProtKB/TrEMBL
      Q8BLD3
      Conserved Domains (1) summary
      cd00176
      Location:132356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RNA

    1. XR_001783148.3 RNA Sequence

    2. XR_003953673.2 RNA Sequence