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    Slc2a7 solute carrier family 2 (facilitated glucose transporter), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 435818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc2a7provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 7provided by MGI
    Primary source
    MGI:MGI:3650865
    See related
    Ensembl:ENSMUSG00000062064 AllianceGenome:MGI:3650865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLUT-7
    Summary
    Predicted to enable D-glucose transmembrane transporter activity and fructose transmembrane transporter activity. Predicted to be involved in D-glucose transmembrane transport and fructose transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC2A7 (solute carrier family 2 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 33.3), small intestine adult (RPKM 16.9) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Slc2a7 in Genome Data Viewer
    Location:
    4 E2; 4 81.04 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150233293..150253499)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150148834..150169042)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 157 Neighboring gene STARR-seq mESC enhancer starr_12136 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 5 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149512225-149512526 Neighboring gene predicted gene, 52492 Neighboring gene carbonic anhydrase 6 Neighboring gene STARR-seq mESC enhancer starr_12144 Neighboring gene STARR-positive B cell enhancer ABC_E8035 Neighboring gene enolase 1, alpha non-neuron

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables D-glucose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fructose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables fructose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in D-glucose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dehydroascorbic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in fructose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 7
    Names
    glucose transporter type 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085529.2 → NP_001078998.1  solute carrier family 2, facilitated glucose transporter member 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606971
      Consensus CDS
      CCDS51385.1
      UniProtKB/Swiss-Prot
      P0C6A1
      UniProtKB/TrEMBL
      B1ARZ3
      Related
      ENSMUSP00000059106.8, ENSMUST00000059893.8
      Conserved Domains (2) summary
      cd06174
      Location:93 → 479
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:27 → 494
      Sugar_tr; Sugar (and other) transporter

    2. NM_001368869.1 → NP_001355798.1  solute carrier family 2, facilitated glucose transporter member 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606971
      UniProtKB/Swiss-Prot
      P0C6A1
      Conserved Domains (1) summary
      cd17432
      Location:26 → 478
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150233293..150253499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320304.2 → XP_017175793.1  solute carrier family 2, facilitated glucose transporter member 7 isoform X1

      UniProtKB/Swiss-Prot
      P0C6A1
      Conserved Domains (1) summary
      cd17432
      Location:89 → 518
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    2. XM_030253649.2 → XP_030109509.1  solute carrier family 2, facilitated glucose transporter member 7 isoform X3

      UniProtKB/Swiss-Prot
      P0C6A1
      Conserved Domains (1) summary
      cd17432
      Location:1 → 429
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    3. XM_030253648.2 → XP_030109508.1  solute carrier family 2, facilitated glucose transporter member 7 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:87 → 419
      MFS; Major Facilitator Superfamily

    4. XM_030253650.2 → XP_030109510.1  solute carrier family 2, facilitated glucose transporter member 7 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:1 → 325
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C6A1.1 GenPept UniProtKB/Swiss-Prot:P0C6A1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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