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    Commd8 COMM domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 27784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Commd8provided by MGI
    Official Full Name
    COMM domain containing 8provided by MGI
    Primary source
    MGI:MGI:1343485
    See related
    Ensembl:ENSMUSG00000029213 AllianceGenome:MGI:1343485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Buc26e
    Summary
    Predicted to enable NF-kappaB binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Orthologous to human COMMD8 (COMM domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.6), placenta adult (RPKM 7.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Commd8 in Genome Data Viewer
    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72313919..72325532, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72156576..72168189, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit beta 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13358 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72551776-72552076 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72559343-72559644 Neighboring gene STARR-positive B cell enhancer ABC_E670 Neighboring gene STARR-seq mESC enhancer starr_13361 Neighboring gene STARR-seq mESC enhancer starr_13362 Neighboring gene STARR-seq mESC enhancer starr_13363 Neighboring gene STARR-positive B cell enhancer ABC_E10323 Neighboring gene STARR-positive B cell enhancer ABC_E4761 Neighboring gene ATPase, class V, type 10D Neighboring gene predicted gene, 25768 Neighboring gene corin, serine peptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. Shirai T, et al. Sci Immunol, 2023 Mar 31. PMID 37000855
    2. The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. Nakai A, et al. J Exp Med, 2019 Jul 1. PMID 31088898, Free PMC Article
    3. A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5. Lengeling A, et al. Genome Res, 1999 Aug. PMID 10447508, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106259

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COMM domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356611.1 → NP_001343540.1  COMM domain-containing protein 8 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC122915, CB247520
      Conserved Domains (1) summary
      cd04756
      Location:6 → 165
      Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    2. NM_001356612.1 → NP_001343541.1  COMM domain-containing protein 8 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC122915, BY150959
      UniProtKB/TrEMBL
      A0A0G2JEX2
      Related
      ENSMUSP00000142937.2, ENSMUST00000196241.2
      Conserved Domains (1) summary
      cl06336
      Location:25 → 130
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    3. NM_001356613.1 → NP_001343542.1  COMM domain-containing protein 8 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AC122915, AK158078
      UniProtKB/TrEMBL
      Q80UT2
      Conserved Domains (1) summary
      cl06336
      Location:5 → 110
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    4. NM_001356614.1 → NP_001343543.1  COMM domain-containing protein 8 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and contains an alternate internal exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AC122915, AK017777
      UniProtKB/TrEMBL
      Q80UT2
      Conserved Domains (1) summary
      cl06336
      Location:5 → 110
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    5. NM_178599.5 → NP_848714.1  COMM domain-containing protein 8 isoform a

      See identical proteins and their annotated locations for NP_848714.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC122915
      Consensus CDS
      CCDS39108.1
      UniProtKB/Swiss-Prot
      Q9CZG3, Q9D7F6
      UniProtKB/TrEMBL
      Q4QQP1
      Related
      ENSMUSP00000013693.7, ENSMUST00000013693.11
      Conserved Domains (1) summary
      cd04756
      Location:7 → 182
      Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      72313919..72325532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254548.1 → XP_030110408.1  COMM domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      Q80UT2
      Conserved Domains (1) summary
      cl06336
      Location:5 → 110
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    2. XM_036165159.1 → XP_036021052.1  COMM domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      Q80UT2
      Conserved Domains (1) summary
      cl06336
      Location:5 → 110
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZG3.1 GenPept UniProtKB/Swiss-Prot:Q9CZG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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