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    Zdhhc4 zinc finger, DHHC domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 72881, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zdhhc4provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 4provided by MGI
    Primary source
    MGI:MGI:1920131
    See related
    Ensembl:ENSMUSG00000001844 AllianceGenome:MGI:1920131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHHC-4; 1810021D01Rik; 2900029I10Rik
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in positive regulation of innate immune response; protein localization to plasma membrane; and protein targeting to membrane. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; inner cell mass; oocyte; and pancreas tip epithelium. Orthologous to human ZDHHC4 (zinc finger DHHC-type palmitoyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 86.6), genital fat pad adult (RPKM 21.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc4 in Genome Data Viewer
    Location:
    5 G2; 5 82.08 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143302244..143315007, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143316489..143329268, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52794 Neighboring gene integrator complex subunit 15 Neighboring gene RIKEN cDNA 0610040B10 gene Neighboring gene STARR-seq mESC enhancer starr_14790 Neighboring gene STARR-seq mESC enhancer starr_14791 Neighboring gene glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 Neighboring gene predicted gene, 38736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, et al. Cell Rep, 2019 Jan 2. PMID 30605677
    2. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
    3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC4
    Names
    probable palmitoyltransferase ZDHHC4
    zinc finger DHHC domain-containing protein 4
    NP_001346374.1
    NP_082655.1
    XP_006504796.1
    XP_006504797.1
    XP_006504798.1
    XP_006504799.1
    XP_030110694.1
    XP_030110695.1
    XP_030110696.1
    XP_030110698.1
    XP_036021428.1
    XP_036021429.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359445.1 → NP_001346374.1  palmitoyltransferase ZDHHC4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC123686
      Conserved Domains (1) summary
      pfam01529
      Location:8 → 149
      DHHC; DHHC palmitoyltransferase

    2. NM_028379.5 → NP_082655.1  palmitoyltransferase ZDHHC4 isoform 1

      See identical proteins and their annotated locations for NP_082655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK013609, BB868748, BE853198
      Consensus CDS
      CCDS19840.1
      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Related
      ENSMUSP00000001900.3, ENSMUST00000001900.9
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_153112.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123686
      Related
      ENSMUST00000159813.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143302244..143315007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504735.3 → XP_006504798.1  palmitoyltransferase ZDHHC4 isoform X1

      See identical proteins and their annotated locations for XP_006504798.1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Related
      ENSMUSP00000124813.2, ENSMUST00000161915.8
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    2. XM_006504733.3 → XP_006504796.1  palmitoyltransferase ZDHHC4 isoform X1

      See identical proteins and their annotated locations for XP_006504796.1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    3. XM_036165536.1 → XP_036021429.1  palmitoyltransferase ZDHHC4 isoform X1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    4. XM_006504734.3 → XP_006504797.1  palmitoyltransferase ZDHHC4 isoform X1

      See identical proteins and their annotated locations for XP_006504797.1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    5. XM_036165535.1 → XP_036021428.1  palmitoyltransferase ZDHHC4 isoform X1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    6. XM_006504736.5 → XP_006504799.1  palmitoyltransferase ZDHHC4 isoform X1

      See identical proteins and their annotated locations for XP_006504799.1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    7. XM_030254834.2 → XP_030110694.1  palmitoyltransferase ZDHHC4 isoform X1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    8. XM_030254835.2 → XP_030110695.1  palmitoyltransferase ZDHHC4 isoform X1

      UniProtKB/Swiss-Prot
      Q8R5E0, Q9D6H5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    9. XM_030254836.2 → XP_030110696.1  palmitoyltransferase ZDHHC4 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:8 → 149
      DHHC; DHHC palmitoyltransferase

    10. XM_030254838.2 → XP_030110698.1  palmitoyltransferase ZDHHC4 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:8 → 149
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6H5.1 GenPept UniProtKB/Swiss-Prot:Q9D6H5

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